NADPH oxidase 5 (EC 1.6.3.-)
1_MNTSG 6_ DPAQT 11_ GPEGC 16_ RGTMS 21_ AEEDA 26_ RWLRW 31_ VTQQF 36_ KTIAG 41_ EDGEI 46_ SLQEF 51_ KAALH 56_ VKESF 61_ FAERF 66_ FALFD 71_ SDRSG 76_ TITLQ 81_ ELQEA 86_ LTLLI 91_ HGSPM 96_ DKLKF 101_ LFQVY 106_ DIDVC 111_ ARQGA 116_ SAGTE 121_ WGAGA 126_ GPHWA 131_ SSPLG 136_ TGSGS 141_ IDPDE 146_ LRTVL 151_ QSCLR 156_ ESAIS 161_ LPDEK 166_ LDQLT 171_ LALFE 176_ SADAD 181_ GNGAI 186_ TFEEL 191_ RDELQ 196_ RFPGV 201_ MENLT 206_ ISAAH 211_ WLTAP 216_ APRPR 221_ PRRPR 226_ QLTRA 231_ YWHNH 236_ RSQLF 241_ CLATY 246_ AGLHV 251_ LLFGL 256_ AASAH 261_ RDLGA 266_ SVMVA 271_ KGCGQ 276_ CLNFD 281_ CSFIA 286_ VLMLR 291_ RCLTW 296_ LRATW 301_ LAQVL 306_ PLDQN 311_ IQFHQ 316_ LMGYV 321_ VVGLS 326_ LVHTV 331_ AHTVN 336_ FVLQA 341_ QAEAS 346_ PFQFW 351_ ELLLT 356_ TRPGI 361_ GWVHG 366_ SASPT 371_ GVALL 376_ LLLLL 381_ MFICS 386_ SSCIR 391_ RSGHF 396_ EVFYW 401_ THLSY 406_ LLVWL 411_ LLIFH 416_ GPNFW 421_ KWLLV 426_ PGILF 431_ FLEKA 436_ IGLAV 441_ SRMAA 446_ VCIME 451_ VNLLP 456_ SKVTH 461_ LLIKR 466_ PPFFH 471_ YRPGD 476_ YLYLN 481_ IPTIA 486_ RYEWH 491_ PFTIS 496_ SAPEQ 501_ KDTIW 506_ LHIRS 511_ QGQWT 516_ NRLYE 521_ SFKAS 526_ DPLGR 531_ GSKRL 536_ SRSVT 541_ MRKSQ 546_ RSSKG 551_ SEILL 556_ EKHKF 561_ CNIKC 566_ YIDGP 571_ YGTPT 576_ RRIFA 581_ SEHAV 586_ LIGAG 591_ IGITP 596_ FASIL 601_ QSIMY 606_ RHQKR 611_ KHTCP 616_ SCQHS 621_ WIEGV 626_ QDNMK 631_ LHKVD 636_ FIWIN 641_ RDQRS 646_ FEWFV 651_ SLLTK 656_ LEMDQ 661_ AEEAQ 666_ YGRFL 671_ ELHMY 676_ MTSAL 681_ GKNDM 686_ KAIGL 691_ QMALD 696_ LLANK 701_ EKKDS 706_ ITGLQ 711_ TRTQP 716_ GRPDW 721_ SKVFQ 726_ KVAAE 731_ KKGKV 736_ QVFFC 741_ GSPAL 746_ AKVLK 751_ GHCEK 756_FGFRF
1: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516)
2: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596)
3: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor
4: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838)
5: Lacks calcium-dependent NADPH oxidase activity
6: Lacks calcium-dependent NADPH oxidase activity