Defensin beta 118 (Beta-defensin 18) (DEFB-18) (Epididymal secretory protein 13.6) (ESP13.6)
1_MKLLL 6_ LALPM 11_ LVLLP 16_ QVIPA 21_ YSGEK 26_ KCWNR 31_ SGHCR 36_ KQCKD 41_ GEAVK 46_ DTCKN 51_ LRACC 56_ IPSNE 61_ DHRRV 66_ PATSP 71_ TPLSD 76_ STPGI 81_ IDDIL 86_ TVRFT 91_ TDYFE 96_ VSSKK 101_ DMVEE 106_ SEAGR 111_ GTETS 116_LPNVH
1: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (PubMed:15033915, PubMed:33224970). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (PubMed:33224970). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (PubMed:15033915). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:33181266). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (PubMed:15033915)