RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)
1_MKIFV 6_ GNVDG 11_ ADTTP 16_ EELAA 21_ LFAPY 26_ GTVMS 31_ CAVMK 36_ QFAFV 41_ HMREN 46_ AGALR 51_ AIEAL 56_ HGHEL 61_ RPGRA 66_ LVVEM 71_ SRPRP 76_ LNTWK 81_ IFVGN 86_ VSAAC 91_ TSQEL 96_ RSLFE 101_ RRGRV 106_ IECDV 111_ VKDYA 116_ FVHME 121_ KEADA 126_ KAAIA 131_ QLNGK 136_ EVKGK 141_ RINVE 146_ LSTKG 151_ QKKGP 156_ GLAVQ 161_ SGDKT 166_ KKPGA 171_ GDTAF 176_ PGTGG 181_ FSATF 186_ DYQQA 191_ FGNST 196_ GGFDG 201_ QARQP 206_ TPPFF 211_ GRDRS 216_ PLRRS 221_ PPRAS 226_ YVAPL 231_ TAQPA 236_ TYRAQ 241_ PSVSL 246_ GAAYR 251_ AQPSA 256_ SLGVG 261_ YRTQP 266_ MTAQA 271_ ASYRA 276_ QPSVS 281_ LGAPY 286_ RGQLA 291_ SPSSQ 296_ SAAAS 301_ SLGPY 306_ GGAQP 311_ SASAL 316_ SSYGG 321_ QAAAA 326_ SSLNS 331_ YGAQG 336_ SSLAS 341_ YGNQP 346_ SSYGA 351_ QAASS 356_ YGVRA 361_ AASSY 366_ NTQGA 371_ ASSLG 376_ SYGAQ 381_ AASYG 386_ AQSAA 391_ SSLAY 396_ GAQAA 401_ SYNAQ 406_ PSASY 411_ NAQSA 416_ PYAAQ 421_ QAASY 426_ SSQPA 431_ AYVAQ 436_ PATAA 441_ AYASQ 446_ PAAYA 451_ AQATT 456_ PMAGS 461_ YGAQP 466_ VVQTQ 471_ LNSYG 476_ AQASM 481_ GLSGS 486_ YGAQS 491_ AAAAT 496_ GSYGA 501_ AAAYG 506_ AQPSA 511_ TLAAP 516_ YRTQS 521_ SASLA 526_ ASYAA 531_ QQHPQ 536_ AAASY 541_ RGQPG 546_ NAYDG 551_ AGQPS 556_ AAYLS 561_ MSQGA 566_ VANAN 571_ STPPP 576_ YERTR 581_ LSPPR 586_ ASYDD 591_ PYKKA 596_ VAMSK 601_ RYGSD 606_ RRLAE 611_ LSDYR 616_ RLSES 621_ QLSFR 626_ RSPTK 631_ SSLDY 636_ RRLPD 641_ AHSDY 646_ ARYSG 651_ SYNDY 656_ LRAAQ 661_MHSGY
1: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402)