RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2)
1_MAATA 6_ REDGA 11_ SGQER 16_ GQRGC 21_ EHYDR 26_ GCLLK 31_ APCCD 36_ KLYTC 41_ RLCHD 46_ NNEDH 51_ QLDRF 56_ KVKEV 61_ QCINC 66_ EKIQH 71_ AQQTC 76_ EECST 81_ LFGEY 86_ YCDIC 91_ HLFDK 96_ DKKQY 101_ HCENC 106_ GICRI 111_ GPKED 116_ FFHCL 121_ KCNLC 126_ LAMNL 131_ QGRHK 136_ CIENV 141_ SRQNC 146_ PICLE 151_ DIHTS 156_ RVVAH 161_ VLPCG 166_ HLLHR 171_ TCYEE 176_ MLKEG 181_ YRCPL 186_ CMHSA 191_ LDMTR 196_ YWRQL 201_ DDEVA 206_ QTPMP 211_ SEYQN 216_ MTVDI 221_ LCNDC 226_ NGRST 231_ VQFHI 236_ LGMKC 241_ KICES 246_ YNTAQ 251_ AGGRR 256_ISLDQ
1: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987)
2: Has no E3 ubiquitin-protein ligase activity