Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein)
1_MILGS 6_ LSRAG 11_ PLPLL 16_ RQPPI 21_ MQPPL 26_ DLKQI 31_ LPFPL 36_ EPAPT 41_ LGLFS 46_ NYSTM 51_ DPVQK 56_ AVLSH 61_ TFGGP 66_ LLKTK 71_ RPVIS 76_ CNICQ 81_ IRFNS 86_ QSQAE 91_ AHYKG 96_ NRHAR 101_ RVKGI 106_ EAAKT 111_ RGREP 116_ GVREP 121_ GDPAP 126_ PGSTP 131_ TNGDG 136_ VAPRP 141_ VSMEN 146_ GLGPA 151_ PGSPE 156_ KQPGS 161_ PSPPS 166_ IPETG 171_ QGVTK 176_ GEGGT 181_ PAPAS 186_ LPGGS 191_ KEEEE 196_ KAKRL 201_ LYCAL 206_ CKVAV 211_ NSLSQ 216_ LEAHN 221_ KGTKH 226_ KTILE 231_ ARSGL 236_ GPIKA 241_ YPRLG 246_ PPTPG 251_ EPEAP 256_ AQDRT 261_ FHCEI 266_ CNVKV 271_ NSEVQ 276_ LKQHI 281_ SSRRH 286_ RDGVA 291_ GKPNP 296_ LLSRH 301_ KKSRG 306_ AGELA 311_ GTLTF 316_ SKELP 321_ KSLAG 326_ GLLPS 331_ PLAVA 336_ AVMAA 341_ AAGSP 346_ LSLRP 351_ APAAP 356_ LLQGP 361_ PITHP 366_ LLHPA 371_ PGPIR 376_ TAHGP 381_ILFSP
1: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation