Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)
1_MALEI 6_ HMSDP 11_ MCLIE 16_ NFNEQ 21_ LKVNQ 26_ EALEI 31_ LSAIT 36_ QPVVV 41_ VAIVG 46_ LYRTG 51_ KSYLM 56_ NKLAG 61_ KNKGF 66_ SVAST 71_ VQSHT 76_ KGIWI 81_ WCVPH 86_ PNWPN 91_ HTLVL 96_ LDTEG 101_ LGDVE 106_ KADNK 111_ NDIQI 116_ FALAL 121_ LLSST 126_ FVYNT 131_ VNKID 136_ QGAID 141_ LLHNV 146_ TELTD 151_ LLKAR 156_ NSPDL 161_ DRVED 166_ PADSA 171_ SFFPD 176_ LVWTL 181_ RDFCL 186_ GLEID 191_ GQLVT 196_ PDEYL 201_ ENSLR 206_ PKQGS 211_ DQRVQ 216_ NFNLP 221_ RLCIQ 226_ KFFPK 231_ KKCFI 236_ FDLPA 241_ HQKKL 246_ AQLET 251_ LPDDE 256_ LEPEF 261_ VQQVT 266_ EFCSY 271_ IFSHS 276_ MTKTL 281_ PGGIM 286_ VNGSR 291_ LKNLV 296_ LTYVN 301_ AISSG 306_ DLPCI 311_ ENAVL 316_ ALAQR 321_ ENSAA 326_ VQKAI 331_ AHYDQ 336_ QMGQK 341_ VQLPM 346_ ETLQE 351_ LLDLH 356_ RTSER 361_ EAIEV 366_ FMKNS 371_ FKDVD 376_ QSFQK 381_ ELETL 386_ LDAKQ 391_ NDICK 396_ RNLEA 401_ SSDYC 406_ SALLK 411_ DIFGP 416_ LEEAV 421_ KQGIY 426_ SKPGG 431_ HNLFI 436_ QKTEE 441_ LKAKY 446_ YREPR 451_ KGIQA 456_ EEVLQ 461_ KYLKS 466_ KESVS 471_ HAILQ 476_ TDQAL 481_ TETEK 486_ KKKEA 491_ QVKAE 496_ AEKAE 501_ AQRLA 506_ AIQRQ 511_ NEQMM 516_ QERER 521_ LHQEQ 526_ VRQME 531_ IAKQN 536_ WLAEQ 541_ QKMQE 546_ QQMQE 551_ QAAQL 556_ STTFQ 561_ AQNRS 566_ LLSEL 571_ QHAQR 576_ TVNND 581_DPCVL
1: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448)
2: Antigenic tumor-specific truncated splice form