VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]
1_MAHRG 6_ PSRAS 11_ KGPGP 16_ TARAP 21_ SPGAP 26_ PPPRS 31_ PRSRP 36_ LLLLL 41_ LLLGA 46_ CGAAG 51_ RSPEP 56_ GRLGP 61_ HAQLT 66_ RVPRS 71_ PPAGR 76_ AEPGG 81_ GEDRQ 86_ ARGTE 91_ PGAPG 96_ PSPGP 101_ APGPG 106_ EDGAP 111_ AAGYR 116_ RWERA 121_ APLAG 126_ VASRA 131_ QVSLI 136_ STSFV 141_ LKGDA 146_ THNQA 151_ MVHWT 156_ GENSS 161_ VILIL 166_ TKYYH 171_ ADMGK 176_ VLESS 181_ LWRSS 186_ DFGTS 191_ YTKLT 196_ LQPGV 201_ TTVID 206_ NFYIC 211_ PTNKR 216_ KVILV 221_ SSSLS 226_ DRDQS 231_ LFLSA 236_ DEGAT 241_ FQKQP 246_ IPFFV 251_ ETLIF 256_ HPKEE 261_ DKVLA 266_ YTKES 271_ KLYVS 276_ SDLGK 281_ KWTLL 286_ QERVT 291_ KDHVF 296_ WSVSG 301_ VDADP 306_ DLVHV 311_ EAQDL 316_ GGDFR 321_ YVTCA 326_ IHNCS 331_ EKMLT 336_ APFAG 341_ PIDHG 346_ SLTVQ 351_ DDYIF 356_ FKATS 361_ ANQTK 366_ YYVSY 371_ RRNEF 376_ VLMKL 381_ PKYAL 386_ PKDLQ 391_ IISTD 396_ ESQVF 401_ VAVQE 406_ WYQMD 411_ TYNLY 416_ QSDPR 421_ GVRYA 426_ LVLQD 431_ VRSSR 436_ QAEES 441_ VLIDI 446_ LEVRG 451_ VKGVF 456_ LANQK 461_ IDGKV 466_ MTLIT 471_ YNKGR 476_ DWDYL 481_ RPPSM 486_ DMNGK 491_ PTNCK 496_ PPDCH 501_ LHLHL 506_ RWADN 511_ PYVSG 516_ TVHTK 521_ DTAPG 526_ LIMGA 531_ GNLGS 536_ QLVEY 541_ KEEMY 546_ ITSDC 551_ GHTWR 556_ QVFEE 561_ EHHIL 566_ YLDHG 571_ GVIVA 576_ IKDTS 581_ IPLKI 586_ LKFSV 591_ DEGLT 596_ WSTHN 601_ FTSTS 606_ VFVDG 611_ LLSEP 616_ GDETL 621_ VMTVF 626_ GHISF 631_ RSDWE 636_ LVKVD 641_ FRPSF 646_ SRQCG 651_ EEDYS 656_ SWELS 661_ NLQGD 666_ RCIMG 671_ QQRSF 676_ RKRKS 681_ TSWCI 686_ KGRSF 691_ TSALT 696_ SRVCE 701_ CRDSD 706_ FLCDY 711_ GFERS 716_ SSSES 721_ STNKC 726_ SANFW 731_ FNPLS 736_ PPDDC 741_ ALGQT 746_ YTSSL 751_ GYRKV 756_ VSNVC 761_ EGGVD 766_ MQQSQ 771_ VQLQC 776_ PLTPP 781_ RGLQV 786_ SIQGE 791_ AVAVR 796_ PGEDV 801_ LFVVR 806_ QEQGD 811_ VLTTK 816_ YQVDL 821_ GDGFK 826_ AMYVN 831_ LTLTG 836_ EPIRH 841_ RYESP 846_ GIYRV 851_ SVRAE 856_ NTAGH 861_ DEAVL 866_ FVQVN 871_ SPLQA 876_ LYLEV 881_ VPVIG 886_ LNQEV 891_ NLTAV 896_ LLPLN 901_ PNLTV 906_ FYWWI 911_ GHSLQ 916_ PLLSL 921_ DNSVT 926_ TRFSD 931_ TGDVR 936_ VTVQA 941_ ACGNS 946_ VLQDS 951_ RVLRV 956_ LDQFQ 961_ VMPLQ 966_ FSKEL 971_ DAYNP 976_ NTPEW 981_ REDVG 986_ LVVTR 991_ LLSKE 996_ TSVPQ 1001_ ELLVT 1006_ VVKPG 1011_ LPTLA 1016_ DLYVL 1021_ LPPPR 1026_ PTRKR 1031_ SLSSD 1036_ KRLAA 1041_ IQQVL 1046_ NAQKI 1051_ SFLLR 1056_ GGVRV 1061_ LVALR 1066_ DTGTG 1071_ AEQLG 1076_ GGGGY 1081_ WAVVV 1086_ LFVIG 1091_ LFAAG 1096_ AFILY 1101_ KFKRK 1106_ RPGRT 1111_ VYAQM 1116_ HNEKE 1121_ QEMTS 1126_ PVSHS 1131_ EDVQG 1136_ AVQGN 1141_ HSGVV 1146_ LSINS 1151_REMHS
1: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity)
2: Does not promote Schwann cell apoptosis in response to proBDNF
3: SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF