E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
1_MWIQV 6_ RTIDG 11_ SKTCT 16_ IEDVS 21_ RKATI 26_ EELRE 31_ RVWAL 36_ FDVRP 41_ ECQRL 46_ FYRGK 51_ QLENG 56_ YTLFD 61_ YDVGL 66_ NDIIQ 71_ LLVRP 76_ DPDHL 81_ PGTST 86_ QIEAK 91_ PCSNS 96_ PPKVK 101_ KAPRV 106_ GPSNQ 111_ PSTSA 116_ RARLI 121_ DPGFG 126_ IYKVN 131_ ELVDA 136_ RDVGL 141_ GAWFE 146_ AHIHS 151_ VTRAS 156_ DGQSR 161_ GKTPL 166_ KNGSS 171_ CKRTN 176_ GNIKH 181_ KSKEN 186_ TNKLD 191_ SVPST 196_ SNSDC 201_ VAADE 206_ DVIYH 211_ IQYDE 216_ YPESG 221_ TLEMN 226_ VKDLR 231_ PRART 236_ ILKWN 241_ ELNVG 246_ DVVMV 251_ NYNVE 256_ SPGQR 261_ GFWFD 266_ AEITT 271_ LKTIS 276_ RTKKE 281_ LRVKI 286_ FLGGS 291_ EGTLN 296_ DCKII 301_ SVDEI 306_ FKIER 311_ PGAHP 316_ LSFAD 321_ GKFLR 326_ RNDPE 331_ CDLCG 336_ GDPEK 341_ KCHSC 346_ SCRVC 351_ GGKHE 356_ PNMQL 361_ LCDEC 366_ NVAYH 371_ IYCLN 376_ PPLDK 381_ VPEEE 386_ YWYCP 391_ SCKTD 396_ SSEVV 401_ KAGER 406_ LKMSK 411_ KKAKM 416_ PSAST 421_ ESRRD 426_ WGRGM 431_ ACVGR 436_ TRECT 441_ IVPSN 446_ HYGPI 451_ PGIPV 456_ GSTWR 461_ FRVQV 466_ SEAGV 471_ HRPHV 476_ GGIHG 481_ RSNDG 486_ AYSLV 491_ LAGGF 496_ ADEVD 501_ RGDEF 506_ TYTGS 511_ GGKNL 516_ AGNKR 521_ IGAPS 526_ ADQTL 531_ TNMNR 536_ ALALN 541_ CDAPL 546_ DDKIG 551_ AESRN 556_ WRAGK 561_ PVRVI 566_ RSFKG 571_ RKISK 576_ YAPEE 581_ GNRYD 586_ GIYKV 591_ VKYWP 596_ EISSS 601_ HGFLV 606_ WRYLL 611_ RRDDV 616_ EPAPW 621_ TSEGI 626_ ERSRR 631_ LCLRL 636_ QYPAG 641_ YPSDK 646_ EGKKP 651_ KGQSK 656_ KQPSG 661_ TTKRP 666_ ISDDD 671_ CPSAS 676_ KVYKA 681_ SDSAE 686_ AIEAF 691_ QLTPQ 696_ QQHLI 701_ REDCQ 706_ NQKLW 711_ DEVLS 716_ HLVEG 721_ PNFLK 726_ KLEQS 731_ FMCVC 736_ CQELV 741_ YQPVT 746_ TECFH 751_ NVCKD 756_ CLQRS 761_ FKAQV 766_ FSCPA 771_ CRHDL 776_ GQNYI 781_ MIPNE 786_ ILQTL 791_ LDLFF 796_PGYSK
1: E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395)