E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
1_MATGL 6_ GEPVY 11_ GLSED 16_ EGESR 21_ ILRVK 26_ VVSGI 31_ DLAKK 36_ DIFGA 41_ SDPYV 46_ KLSLY 51_ VADEN 56_ RELAL 61_ VQTKT 66_ IKKTL 71_ NPKWN 76_ EEFYF 81_ RVNPS 86_ NHRLL 91_ FEVFD 96_ ENRLT 101_ RDDFL 106_ GQVDV 111_ PLSHL 116_ PTEDP 121_ TMERP 126_ YTFKD 131_ FLLRP 136_ RSHKS 141_ RVKGF 146_ LRLKM 151_ AYMPK 156_ NGGQD 161_ EENSD 166_ QRDDM 171_ EHGWE 176_ VVDSN 181_ DSASQ 186_ HQEEL 191_ PPPPL 196_ PPGWE 201_ EKVDN 206_ LGRTY 211_ YVNHN 216_ NRTTQ 221_ WHRPS 226_ LMDVS 231_ SESDN 236_ NIRQI 241_ NQEAA 246_ HRRFR 251_ SRRHI 256_ SEDLE 261_ PEPSE 266_ GGDVP 271_ EPWET 276_ ISEEV 281_ NIAGD 286_ SLGLA 291_ LPPPP 296_ ASPGS 301_ RTSPQ 306_ ELSEE 311_ LSRRL 316_ QITPD 321_ SNGEQ 326_ FSSLI 331_ QREPS 336_ SRLRS 341_ CSVTD 346_ AVAEQ 351_ GHLPP 356_ PSAPA 361_ GRARS 366_ STVTG 371_ GEEPT 376_ PSVAY 381_ VHTTP 386_ GLPSG 391_ WEERK 396_ DAKGR 401_ TYYVN 406_ HNNRT 411_ TTWTR 416_ PIMQL 421_ AEDGA 426_ SGSAT 431_ NSNNH 436_ LIEPQ 441_ IRRPR 446_ SLSSP 451_ TVTLS 456_ APLEG 461_ AKDSP 466_ VRRAV 471_ KDTLS 476_ NPQSP 481_ QPSPY 486_ NSPKP 491_ QHKVT 496_ QSFLP 501_ PGWEM 506_ RIAPN 511_ GRPFF 516_ IDHNT 521_ KTTTW 526_ EDPRL 531_ KFPVH 536_ MRSKT 541_ SLNPN 546_ DLGPL 551_ PPGWE 556_ ERIHL 561_ DGRTF 566_ YIDHN 571_ SKITQ 576_ WEDPR 581_ LQNPA 586_ ITGPA 591_ VPYSR 596_ EFKQK 601_ YDYFR 606_ KKLKK 611_ PADIP 616_ NRFEM 621_ KLHRN 626_ NIFEE 631_ SYRRI 636_ MSVKR 641_ PDVLK 646_ ARLWI 651_ EFESE 656_ KGLDY 661_ GGVAR 666_ EWFFL 671_ LSKEM 676_ FNPYY 681_ GLFEY 686_ SATDN 691_ YTLQI 696_ NPNSG 701_ LCNED 706_ HLSYF 711_ TFIGR 716_ VAGLA 721_ VFHGK 726_ LLDGF 731_ FIRPF 736_ YKMML 741_ GKQIT 746_ LNDME 751_ SVDSE 756_ YYNSL 761_ KWILE 766_ NDPTE 771_ LDLMF 776_ CIDEE 781_ NFGQT 786_ YQVDL 791_ KPNGS 796_ EIMVT 801_ NENKR 806_ EYIDL 811_ VIQWR 816_ FVNRV 821_ QKQMN 826_ AFLEG 831_ FTELL 836_ PIDLI 841_ KIFDE 846_ NELEL 851_ LMCGL 856_ GDVDV 861_ NDWRQ 866_ HSIYK 871_ NGYCP 876_ NHPVI 881_ QWFWK 886_ AVLLM 891_ DAEKR 896_ IRLLQ 901_ FVTGT 906_ SRVPM 911_ NGFAE 916_ LYGSN 921_ GPQLF 926_ TIEQW 931_ GSPEK 936_ LPRAH 941_ TCFNR 946_ LDLPP 951_ YETFE 956_ DLREK 961_ LLMAV 966_ENAQG
1: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513)