E3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157)
1_MGALT 6_ SRQHA 11_ GVEEV 16_ DIPSN 21_ SVYRY 26_ PPKSG 31_ SYFAS 36_ HFIMG 41_ GEKFD 46_ STHPE 51_ GYLFG 56_ ENSDL 61_ NFLGN 66_ RPVVF 71_ PYAAP 76_ PPQEP 81_ VKTLR 86_ SLVNI 91_ RKDTL 96_ RLVKC 101_ AEEVK 106_ SPGEE 111_ ASKAK 116_ VHYNV 121_ EFTFD 126_ TDARV 131_ AITIY 136_ YQATE 141_ EFQNG 146_ IASYI 151_ PKDNS 156_ LQSET 161_ VQYKR 166_ GVCQQ 171_ FCLPS 176_ HTVDP 181_ SEWAE 186_ EELGF 191_ DLDRE 196_ VYPLV 201_ VHAVV 206_ DEGDE 211_ YFGHC 216_ HVLLG 221_ TFEKH 226_ TDGTF 231_ CVKPL 236_ KQKQV 241_ VDGVS 246_ YLLQE 251_ IYGIE 256_ NKYNT 261_ QDSKV 266_ AEDEV 271_ SDNSA 276_ ECVVC 281_ LSDVR 286_ DTLIL 291_ PCRHL 296_ CLCNT 301_ CADTL 306_ RYQAN 311_ NCPIC 316_ RLPFR 321_ ALLQI 326_ RAMRK 331_ KLGPL 336_ SPTSF 341_ NPIIS 346_ SQTSD 351_ SEEHP 356_ SSENI 361_ PPGYE 366_ VVSLL 371_ EALNG 376_ PLTPS 381_ PAVPP 386_ LHVLG 391_ DGHLS 396_ GMLPS 401_ YGSDG 406_ HLPPV 411_ RTISP 416_ LDRLS 421_ DSSSQ 426_ GLKLK 431_ KSLSK 436_ STSQN 441_ SSVLH 446_ EEEDE 451_ HSCSE 456_ SETQL 461_ SQRPS 466_ VQHLG 471_ EECGV 476_ TPESE 481_ NLTLS 486_ SSGAI 491_ DQSSC 496_ TGTPL 501_ SSTIS 506_ SPEGP 511_ ASSSL 516_ AQSVM 521_ SMASS 526_ QISTD 531_ TVSSM 536_ SGSYI 541_ APGTE 546_ EEGEA 551_ LSSPQ 556_ PASRA 561_ PSEEG 566_ EGLPA 571_ ESPDS 576_ NFAGL 581_ PAGEQ 586_ DAEGN 591_ DVIEE 596_ EDGSP 601_ TQEGQ 606_ RTCAF 611_ LGMEC 616_ DNNND 621_ FDIAS 626_ VKALD 631_ NKLCS 636_ EVCLP 641_ GAWQA 646_ DDNAV 651_ SRNAQ 656_ RRRLS 661_ SSSLE 666_ DSETR 671_PCVWG
1: E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764)