Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
1_MEKYV 6_ RLQKI 11_ GEGSF 16_ GKAIL 21_ VKSTE 26_ DGRQY 31_ VIKEI 36_ NISRM 41_ SSKER 46_ EESRR 51_ EVAVL 56_ ANMKH 61_ PNIVQ 66_ YRESF 71_ EENGS 76_ LYIVM 81_ DYCEG 86_ GDLFK 91_ RINAQ 96_ KGVLF 101_ QEDQI 106_ LDWFV 111_ QICLA 116_ LKHVH 121_ DRKIL 126_ HRDIK 131_ SQNIF 136_ LTKDG 141_ TVQLG 146_ DFGIA 151_ RVLNS 156_ TVELA 161_ RTCIG 166_ TPYYL 171_ SPEIC 176_ ENKPY 181_ NNKSD 186_ IWALG 191_ CVLYE 196_ LCTLK 201_ HAFEA 206_ GSMKN 211_ LVLKI 216_ ISGSF 221_ PPVSL 226_ HYSYD 231_ LRSLV 236_ SQLFK 241_ RNPRD 246_ RPSVN 251_ SILEK 256_ GFIAK 261_ RIEKF 266_ LSPQL 271_ IAEEF 276_ CLKTF 281_ SKFGS 286_ QPIPA 291_ KRPAS 296_ GQNSI 301_ SVMPA 306_ QKITK 311_ PAAKY 316_ GIPLA 321_ YKKYG 326_ DKKLH 331_ EKKPL 336_ QKHKQ 341_ AHQTP 346_ EKRVN 351_ TGEER 356_ RKISE 361_ EAARK 366_ RRLEF 371_ IEKEK 376_ KQKDQ 381_ IISLM 386_ KAEQM 391_ KRQEK 396_ ERLER 401_ INRAR 406_ EQGWR 411_ NVLSA 416_ GGSGE 421_ VKAPF 426_ LGSGG 431_ TIAPS 436_ SFSSR 441_ GQYEH 446_ YHAIF 451_ DQMQQ 456_ QRAED 461_ NEAKW 466_ KREIY 471_ GRGLP 476_ ERGIL 481_ PGVRP 486_ GFPYG 491_ AAGHH 496_ HFPDA 501_ DDIRK 506_ TLKRL 511_ KAVSK 516_ QANAN 521_ RQKGQ 526_ LAVER 531_ AKQVE 536_ EFLQR 541_ KREAM 546_ QNKAR 551_ AEGHM 556_ VYLAR 561_ LRQIR 566_ LQNFN 571_ ERQQI 576_ KAKLR 581_ GEKKE 586_ ANHSE 591_ GQEGS 596_ EEADM 601_ RRKKI 606_ ESLKA 611_ HANAR 616_ AAVLK 621_ EQLER 626_ KRKEA 631_ YEREK 636_ KVWEE 641_ HLVAK 646_ GVKSS 651_ DVSPP 656_ LGQHE 661_ TGGSP 666_ SKQQM 671_ RSVIS 676_ VTSAL 681_ KEVGV 686_ DSSLT 691_ DTRET 696_ SEEMQ 701_ KTNNA 706_ ISSKR 711_ EILRR 716_ LNENL 721_ KAQED 726_ EKGKQ 731_ NLSDT 736_ FEINV 741_ HEDAK 746_ EHEKE 751_ KSVSS 756_ DRKKW 761_ EAGGQ 766_ LVIPL 771_ DELTL 776_ DTSFS 781_ TTERH 786_ TVGEV 791_ IKLGP 796_ NGSPR 801_ RAWGK 806_ SPTDS 811_ VLKIL 816_ GEAEL 821_ QLQTE 826_ LLENT 831_ TIRSE 836_ ISPEG 841_ EKYKP 846_ LITGE 851_ KKVQC 856_ ISHEI 861_ NPSAI 866_ VDSPV 871_ ETKSP 876_ EFSEA 881_ SPQMS 886_ LKLEG 891_ NLEEP 896_ DDLET 901_ EILQE 906_ PSGTN 911_ KDESL 916_ PCTIT 921_ DVWIS 926_ EEKET 931_ KETQS 936_ ADRIT 941_ IQENE 946_ VSEDG 951_ VSSTV 956_ DQLSD 961_ IHIEP 966_ GTNDS 971_ QHSKC 976_ DVDKS 981_ VQPEP 986_ FFHKV 991_ VHSEH 996_ LNLVP 1001_ QVQSV 1006_ QCSPE 1011_ ESFAF 1016_ RSHSH 1021_ LPPKN 1026_ KNKNS 1031_ LLIGL 1036_ STGLF 1041_ DANNP 1046_ KMLRT 1051_ CSLPD 1056_ LSKLF 1061_ RTLMD 1066_ VPTVG 1071_ DVRQD 1076_ NLEID 1081_ EIEDE 1086_ NIKEG 1091_ PSDSE 1096_ DIVFE 1101_ ETDTD 1106_ LQELQ 1111_ ASMEQ 1116_ LLREQ 1121_ PGEEY 1126_ SEEEE 1131_ SVLKN 1136_ SDVEP 1141_ TANGT 1146_ DVADE 1151_ DDNPS 1156_ SESAL 1161_ NEEWH 1166_ SDNSD 1171_ GEIAS 1176_ ECECD 1181_ SVFNH 1186_ LEELR 1191_ LHLEQ 1196_ EMGFE 1201_ KFFEV 1206_ YEKIK 1211_ AIHED 1216_ EDENI 1221_ EICSK 1226_ IVQNI 1231_ LGNEH 1236_ QHLYA 1241_ KILHL 1246_ VMADG 1251_AYQED
1: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617)