Pseudouridylate synthase 7 homolog (EC 5.4.99.-)
1_MEMTE 6_ MTGVS 11_ LKRGA 16_ LVVED 21_ NDSGV 26_ PVEET 31_ KKQKL 36_ SECSL 41_ TKGQD 46_ GLQND 51_ FLSIS 56_ EDVPR 61_ PPDTV 66_ STGKG 71_ GKNSE 76_ AQLED 81_ EEEEE 86_ EDGLS 91_ EECEE 96_ EESES 101_ FADMM 106_ KHGLT 111_ EADVG 116_ ITKFV 121_ SSHQG 126_ FSGIL 131_ KERYS 136_ DFVVH 141_ EIGKD 146_ GRISH 151_ LNDLS 156_ IPVDE 161_ EDPSE 166_ DIFTV 171_ LTAEE 176_ KQRLE 181_ ELQLF 186_ KNKET 191_ SVAIE 196_ VIEDT 201_ KEKRT 206_ IIHQA 211_ IKSLF 216_ PGLET 221_ KTEDR 226_ EGKKY 231_ IVAYH 236_ AAGKK 241_ ALANP 246_ RKHSW 251_ PKSRG 256_ SYCHF 261_ VLYKE 266_ NKDTM 271_ DAINV 276_ LSKYL 281_ RVKPN 286_ IFSYM 291_ GTKDK 296_ RAITV 301_ QEIAV 306_ LKITA 311_ QRLAH 316_ LNKCL 321_ MNFKL 326_ GNFSY 331_ QKNPL 336_ KLGEL 341_ QGNHF 346_ TVVLR 351_ NITGT 356_ DDQVQ 361_ QAMNS 366_ LKEIG 371_ FINYY 376_ GMQRF 381_ GTTAV 386_ PTYQV 391_ GRAIL 396_ QNSWT 401_ EVMDL 406_ ILKPR 411_ SGAEK 416_ GYLVK 421_ CREEW 426_ AKTKD 431_ PTAAL 436_ RKLPV 441_ KRCVE 446_ GQLLR 451_ GLSKY 456_ GMKNI 461_ VSAFG 466_ IIPRN 471_ NRLMY 476_ IHSYQ 481_ SYVWN 486_ NMVSK 491_ RIEDY 496_ GLKPV 501_ PGDLV 506_ LKGAT 511_ ATYIE 516_ EDDVN 521_ NYSIH 526_ DVVMP 531_ LPGFD 536_ VIYPK 541_ HKIQE 546_ AYREM 551_ LTADN 556_ LDIDN 561_ MRHKI 566_ RDYSL 571_ SGAYR 576_ KIIIR 581_ PQNVS 586_ WEVVA 591_ YDDPK 596_ IPLFN 601_ TDVDN 606_ LEGKT 611_ PPVFA 616_ SEGKY 621_ RALKM 626_ DFSLP 631_ PSTYA 636_ TMAIR 641_ EVLKM 646_ DTSIK 651_ NQTQL 656_NTTWL
1: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141)