Serine protease FAM111A (EC 3.4.21.-)
1_MSCKK 6_ QRSRK 11_ HSVNE 16_ KCNMK 21_ IEHYF 26_ SPVSK 31_ EQQNN 36_ CSTSL 41_ MRMES 46_ RGDPR 51_ ATTNT 56_ QAQRF 61_ HSPKK 66_ NPEDQ 71_ TMPQN 76_ RTIYV 81_ TLKVN 86_ HRRNQ 91_ DMKLK 96_ LTHSE 101_ NSSLY 106_ MALNT 111_ LQAVR 116_ KEIET 121_ HQGQE 126_ MLVRG 131_ TEGIK 136_ EYINL 141_ GMPLS 146_ CFPEG 151_ GQVVI 156_ TFSQS 161_ KSKQK 166_ EDNHI 171_ FGRQD 176_ KASTE 181_ CVKFY 186_ IHAIG 191_ IGKCK 196_ RRIVK 201_ CGKLH 206_ KKGRK 211_ LCVYA 216_ FKGET 221_ IKDAL 226_ CKDGR 231_ FLSFL 236_ ENDDW 241_ KLIEN 246_ NDTIL 251_ ESTQP 256_ VDELE 261_ GRYFQ 266_ VEVEK 271_ RMVPS 276_ AAASQ 281_ NPESE 286_ KRNTC 291_ VLREQ 296_ IVAQY 301_ PSLKR 306_ ESEKI 311_ IENFK 316_ KKMKV 321_ KNGET 326_ LFELH 331_ RTTFG 336_ KVTKN 341_ SSSIK 346_ VVKLL 351_ VRLSD 356_ SVGYL 361_ FWDSA 366_ TTGYA 371_ TCFVF 376_ KGLFI 381_ LTCRH 386_ VIDSI 391_ VGDGI 396_ EPSKW 401_ ATIIG 406_ QCVRV 411_ TFGYE 416_ ELKDK 421_ ETNYF 426_ FVEPW 431_ FEIHN 436_ EELDY 441_ AVLKL 446_ KENGQ 451_ QVPME 456_ LYNGI 461_ TPVPL 466_ SGLIH 471_ IIGHP 476_ YGEKK 481_ QIDAC 486_ AVIPQ 491_ GQRAK 496_ KCQER 501_ VQSKK 506_ AESPE 511_ YVHMY 516_ TQRSF 521_ QKIVH 526_ NPDVI 531_ TYDTE 536_ FFFGA 541_ SGSPV 546_ FDSKG 551_ SLVAM 556_ HAAGF 561_ AYTYQ 566_ NETRS 571_ IIEFG 576_ STMES 581_ ILLDI 586_ KQRHK 591_ PWYEE 596_ VFVNQ 601_ QDVEM 606_MSDED
1: Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234)