Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)
1_MSRRA 6_ PGSRL 11_ SSGGG 16_ GGGTK 21_ YPRSW 26_ NDWQP 31_ RTDSA 36_ SADPD 41_ NLKYS 46_ SSRDR 51_ GGSSS 56_ YGLQP 61_ SNSAV 66_ VSRQR 71_ HDDTR 76_ VHADI 81_ QNDEK 86_ GGYSV 91_ NGGSG 96_ ENTYG 101_ RKSLG 106_ QELRV 111_ NNVTS 116_ PEFTS 121_ VQHGS 126_ RALAT 131_ KDMRK 136_ SQERS 141_ MSYSD 146_ ESRLS 151_ NLLRR 156_ ITRED 161_ DRDRR 166_ LATVK 171_ QLKEF 176_ IQQPE 181_ NKLVL 186_ VKQLD 191_ NILAA 196_ VHDVL 201_ NESSK 206_ LLQEL 211_ RQEGA 216_ CCLGL 221_ LCASL 226_ SYEAE 231_ KIFKW 236_ IFSKF 241_ SSSAK 246_ DEVKL 251_ LYLCA 256_ TYKAL 261_ ETVGE 266_ KKAFS 271_ SVMQL 276_ VMTSL 281_ QSILE 286_ NVDTP 291_ ELLCK 296_ CVKCI 301_ LLVAR 306_ CYPHI 311_ FSTNF 316_ RDTVD 321_ ILVGW 326_ HIDHT 331_ QKPSL 336_ TQQVS 341_ GWLQS 346_ LEPFW 351_ VADLA 356_ FSTTL 361_ LGQFL 366_ EDMEA 371_ YAEDL 376_ SHVAS 381_ GESVD 386_ EDVPP 391_ PSVSL 396_ PKLAA 401_ LLRVF 406_ STVVR 411_ SIGER 416_ FSPIR 421_ GPPIT 426_ EAYVT 431_ DVLYR 436_ VMRCV 441_ TAANQ 446_ VFFSE 451_ AVLTA 456_ ANECV 461_ GVLLG 466_ SLDPS 471_ MTIHC 476_ DMVIT 481_ YGLDQ 486_ LENCQ 491_ TCGTD 496_ YIISV 501_ LNLLT 506_ LIVEQ 511_ INTKL 516_ PSSFV 521_ EKLFI 526_ PSSKL 531_ LFLRY 536_ HKEKE 541_ VVAVA 546_ HAVYQ 551_ AVLSL 556_ KNIPV 561_ LETAY 566_ KLILG 571_ EMTCA 576_ LNNLL 581_ HSLQL 586_ PEACS 591_ EIKHE 596_ AFKNH 601_ VFNVD 606_ NAKFV 611_ VIFDL 616_ SALTT 621_ IGNAK 626_ NSLIG 631_ MWALS 636_ PTVFA 641_ LLSKN 646_ LMIVH 651_ SDLAV 656_ HFPAI 661_ QYAVL 666_ YTLYS 671_ HCTRH 676_ DHFIS 681_ SSLSS 686_ SSPSL 691_ FDGAV 696_ ISTVT 701_ TATKK 706_ HFSII 711_ LNLLG 716_ ILLKK 721_ DNLNQ 726_ DTRKL 731_ LMTWA 736_ LEAAV 741_ LMKKS 746_ ETYAP 751_ LFSLP 756_ SFHKF 761_ CKGLL 766_ ANTLV 771_ EDVNI 776_ CLQAC 781_ SSLHA 786_ LSSSL 791_ PDDLL 796_ QRCVD 801_ VCRVQ 806_ LVHSG 811_ TRIRQ 816_ AFGKL 821_ LKSIP 826_ LDVVL 831_ SNNNH 836_ TEIQE 841_ ISLAL 846_ RSHMS 851_ KAPSN 856_ TFHPQ 861_ DFSDV 866_ ISFIL 871_ YGNSH 876_ RTGKD 881_ NWLER 886_ LFYSC 891_ QRLDK 896_ RDQST 901_ IPRNL 906_ LKTDA 911_ VLWQW 916_ AIWEA 921_ AQFTV 926_ LSKLR 931_ TPLGR 936_ AQDTF 941_ QTIEG 946_ IIRSL 951_ AAHTL 956_ NPDQD 961_ VSQWT 966_ TADND 971_ EGHGN 976_ NQLRL 981_ VLLLQ 986_ YLENL 991_ EKLMY 996_ NAYEG 1001_ CANAL 1006_ TSPPK 1011_ VIRTF 1016_ FYTNR 1021_ QTCQD 1026_ WLTRI 1031_ RLSIM 1036_ RVGLL 1041_ AGQPA 1046_ VTVRH 1051_ GFDLL 1056_ TEMKT 1061_ TSLSQ 1066_ GNELE 1071_ VTIMM 1076_ VVEAL 1081_ CELHC 1086_ PEAIQ 1091_ GIAVW 1096_ SSSIV 1101_ GKNLL 1106_ WINSV 1111_ AQQAE 1116_ GRFEK 1121_ ASVEY 1126_ QEHLC 1131_ AMTGV 1136_ DCCIS 1141_ SFDKS 1146_ VLTLA 1151_ NAGRN 1156_ SASPK 1161_ HSLNG 1166_ ESRKT 1171_ VLSKP 1176_ TDSSP 1181_ EVINY 1186_ LGNKA 1191_ CECYI 1196_ SIADW 1201_ AAVQE 1206_ WQNAI 1211_ HDLKK 1216_ STSST 1221_ SLNLK 1226_ ADFNY 1231_ IKSLS 1236_ SFESG 1241_ KFVEC 1246_ TEQLE 1251_ LLPGE 1256_ NINLL 1261_ AGGSK 1266_ EKIDM 1271_ KKLLP 1276_ NMLSP 1281_ DPREL 1286_ QKSIE 1291_ VQLLR 1296_ SSVCL 1301_ ATALN 1306_ PIEQD 1311_ QKWQS 1316_ ITENV 1321_ VKYLK 1326_ QTSRI 1331_ AIGPL 1336_ RLSTL 1341_ TVSQS 1346_ LPVLS 1351_ TLQLY 1356_ CSSAL 1361_ ENTVS 1366_ NRLST 1371_ EDCLI 1376_ PLFSE 1381_ ALRSC 1386_ KQHDV 1391_ RPWMQ 1396_ ALRYT 1401_ MYQNQ 1406_ LLEKI 1411_ KEQTV 1416_ PIRSH 1421_ LMELG 1426_ LTAAK 1431_ FARKR 1436_ GNVSL 1441_ ATRLL 1446_ AQCSE 1451_ VQLGK 1456_ TTTAQ 1461_ DLVQH 1466_ FKKLS 1471_ TQGQV 1476_ DEKWG 1481_ PELDI 1486_ EKTKL 1491_ LYTAG 1496_ QSTHA 1501_ MEMLS 1506_ SCAIS 1511_ FCKSV 1516_ KAEYA 1521_ VAKSI 1526_ LTLAK 1531_ WIQAE 1536_ WKEIS 1541_ GQLKQ 1546_ VYRAQ 1551_ HQQNF 1556_ TGLST 1561_ LSKNI 1566_ LTLIE 1571_ LPSVN 1576_ TMEEE 1581_ YPRIE 1586_ SESTV 1591_ HIGVG 1596_ EPDFI 1601_ LGQLY 1606_ HLSSV 1611_ QAPEV 1616_ AKSWA 1621_ ALASW 1626_ AYRWG 1631_ RKVVD 1636_ NASQG 1641_ EGVRL 1646_ LPREK 1651_ SEVQN 1656_ LLPDT 1661_ ITEEE 1666_ KERIY 1671_ GILGQ 1676_ AVCRP 1681_ AGIQD 1686_ EDITL 1691_ QITES 1696_ EDNEE 1701_ DDMVD 1706_ VIWRQ 1711_ LISSC 1716_ PWLSE 1721_ LDESA 1726_ TEGVI 1731_ KVWRK 1736_ VVDRI 1741_ FSLYK 1746_ LSCSA 1751_ YFTFL 1756_ KLNAG 1761_ QIPLD 1766_ EDDPR 1771_ LHLSH 1776_ RVEQS 1781_ TDDMI 1786_ VMATL 1791_ RLLRL 1796_ LVKHA 1801_ GELRQ 1806_ YLEHG 1811_ LETTP 1816_ TAPWR 1821_ GIIPQ 1826_ LFSRL 1831_ NHPEV 1836_ YVRQS 1841_ ICNLL 1846_ CRVAQ 1851_ DSPHL 1856_ ILYPA 1861_ IVGTI 1866_ SLSSE 1871_ SQASG 1876_ NKFST 1881_ AIPTL 1886_ LGNIQ 1891_ GEELL 1896_ VSECE 1901_ GGSPP 1906_ ASQDS 1911_ NKDEP 1916_ KSGLN 1921_ EDQAM 1926_ MQDCY 1931_ SKIVD 1936_ KLSSA 1941_ NPTMV 1946_ LQVQM 1951_ LVAEL 1956_ RRVTV 1961_ LWDEL 1966_ WLGVL 1971_ LQQHM 1976_ YVLRR 1981_ IQQLE 1986_ DEVKR 1991_ VQNNN 1996_ TLRKE 2001_ EKIAI 2006_ MREKH 2011_ TALMK 2016_ PIVFA 2021_ LEHVR 2026_ SITAA 2031_ PAETP 2036_ HEKWF 2041_ QDNYG 2046_ DAIEN 2051_ ALEKL 2056_ KTPLN 2061_ PAKPG 2066_ SSWIP 2071_ FKEIM 2076_ LSLQQ 2081_ RAQKR 2086_ ASYIL 2091_ RLEEI 2096_ SPWLA 2101_ AMTNT 2106_ EIALP 2111_ GEVSA 2116_ RDTVT 2121_ IHSVG 2126_ GTITI 2131_ LPTKT 2136_ KPKKL 2141_ LFLGS 2146_ DGKSY 2151_ PYLFK 2156_ GLEDL 2161_ HLDER 2166_ IMQFL 2171_ SIVNT 2176_ MFATI 2181_ NRQET 2186_ PRFHA 2191_ RHYSV 2196_ TPLGT 2201_ RSGLI 2206_ QWVDG 2211_ ATPLF 2216_ GLYKR 2221_ WQQRE 2226_ AALQA 2231_ QKAQD 2236_ SYQTP 2241_ QNPGI 2246_ VPRPS 2251_ ELYYS 2256_ KIGPA 2261_ LKTVG 2266_ LSLDV 2271_ SRRDW 2276_ PLHVM 2281_ KAVLE 2286_ ELMEA 2291_ TPPNL 2296_ LAKEL 2301_ WSSCT 2306_ TPDEW 2311_ WRVTQ 2316_ SYARS 2321_ TAVMS 2326_ MVGYI 2331_ IGLGD 2336_ RHLDN 2341_ VLIDM 2346_ TTGEV 2351_ VHIDY 2356_ NVCFE 2361_ KGKSL 2366_ RVPEK 2371_ VPFRM 2376_ TQNIE 2381_ TALGV 2386_ TGVEG 2391_ VFRLS 2396_ CEQVL 2401_ HIMRR 2406_ GRETL 2411_ LTLLE 2416_ AFVYD 2421_ PLVDW 2426_ TAGGE 2431_ AGFAG 2436_ AVYGG 2441_ GGQQA 2446_ ESKQS 2451_ KREME 2456_ REITR 2461_ SLFSS 2466_ RVAEI 2471_ KVNWF 2476_ KNRDE 2481_ MLVVL 2486_ PKLDG 2491_ SLDEY 2496_ LSLQE 2501_ QLTDV 2506_ EKLQG 2511_ KLLEE 2516_ IEFLE 2521_ GAEGV 2526_ DHPSH 2531_ TLQHR 2536_ YSEHT 2541_ QLQTQ 2546_ QRAVQ 2551_ EAIQV 2556_ KLNEF 2561_ EQWIT 2566_ HYQAA 2571_ FNNLE 2576_ ATQLA 2581_ SLLQE 2586_ ISTQM 2591_ DLGPP 2596_ SYVPA 2601_ TAFLQ 2606_ NAGQA 2611_ HLISQ 2616_ CEQLE 2621_ GEVGA 2626_ LLQQR 2631_ RSVLR 2636_ GCLEQ 2641_ LHHYA 2646_ TVALQ 2651_ YPKAI 2656_ FQKHR 2661_ IEQWK 2666_ TWMEE 2671_ LICNT 2676_ TVERC 2681_ QELYR 2686_ KYEMQ 2691_ YAPQP 2696_ PPTVC 2701_ QFITA 2706_ TEMTL 2711_ QRYAA 2716_ DINSR 2721_ LIRQV 2726_ ERLKQ 2731_ EAVTV 2736_ PVCED 2741_ QLKEI 2746_ ERCIK 2751_ VFLHE 2756_ NGEEG 2761_ SLSLA 2766_ SVIIS 2771_ ALCTL 2776_ TRRNL 2781_ MMEGA 2786_ ASSAG 2791_ EQLVD 2796_ LTSRD 2801_ GAWFL 2806_ EELCS 2811_ MSGNV 2816_ TCLVQ 2821_ LLKQC 2826_ HLVPQ 2831_ DLDIP 2836_ NPMEA 2841_ SETVH 2846_ LANGV 2851_ YTSLQ 2856_ ELNSN 2861_ FRQII 2866_ FPEAL 2871_ RCLMK 2876_ GEYTL 2881_ ESMLH 2886_ ELDGL 2891_ IEQTT 2896_ DGVPL 2901_ QTLVE 2906_ SLQAY 2911_ LRNAA 2916_ MGLEE 2921_ ETHAH 2926_ YIDVA 2931_ RLLHA 2936_ QYGEL 2941_ IQPRN 2946_ GSVDE 2951_ TPKMS 2956_ AGQML 2961_ LVAFD 2966_ GMFAQ 2971_ VETAF 2976_ SLLVE 2981_ KLNKM 2986_ EIPIA 2991_ WRKID 2996_ IIREA 3001_ RSTQV 3006_ NFFDD 3011_ DNHRQ 3016_ VLEEI 3021_ FFLKR 3026_ LQTIK 3031_ EFFRL 3036_ CGTFS 3041_ KTLSG 3046_ SSSLE 3051_ DQNTV 3056_ NGPVQ 3061_ IVNVK 3066_ TLFRN 3071_ SCFSE 3076_ DQMAK 3081_ PIKAF 3086_ TADFV 3091_ RQLLI 3096_ GLPNQ 3101_ ALGLT 3106_ LCSFI 3111_ SALGV 3116_ DIIAQ 3121_ VEAKD 3126_ FGAES 3131_ KVSVD 3136_ DLCKK 3141_ AVEHN 3146_ IQIGK 3151_ FSQLV 3156_ MNRAT 3161_ VLASS 3166_ YDTAW 3171_ KKHDL 3176_ VRRLE 3181_ TSISS 3186_ CKTSL 3191_ QRVQL 3196_ HIAMF 3201_ QWQHE 3206_ DLLIN 3211_ RPQAM 3216_ SVTPP 3221_ PRSAI 3226_ LTSMK 3231_ KKLHT 3236_ LSQIE 3241_ TSIAT 3246_ VQEKL 3251_ AALES 3256_ SIEQR 3261_ LKWAG 3266_ GANPA 3271_ LAPVL 3276_ QDFEA 3281_ TIAER 3286_ RNLVL 3291_ KESQR 3296_ ASQVT 3301_ FLCSN 3306_ IIHFE 3311_ SLRTR 3316_ TAEAL 3321_ NLDAA 3326_ LFELI 3331_ KRCQQ 3336_ MCSFA 3341_ SQFNS 3346_ SVSEL 3351_ ELRLL 3356_ QRVDT 3361_ GLEHP 3366_ IGSSE 3371_ WLLSA 3376_ HKQLT 3381_ QDMST 3386_ QRAIQ 3391_ TEKEQ 3396_ QIETV 3401_ CETIQ 3406_ NLVDN 3411_ IKTVL 3416_ TGHNR 3421_ QLGDV 3426_ KHLLK 3431_ AMAKD 3436_ EEAAL 3441_ ADGED 3446_ VPYEN 3451_ SVRQF 3456_ LGEYK 3461_ SWQDN 3466_ IQTVL 3471_ FTLVQ 3476_ AMGQV 3481_ RSQEH 3486_ VEMLQ 3491_ EITPT 3496_ LKELK 3501_ TQSQS 3506_ IYNNL 3511_ VSFAS 3516_ PLVTD 3521_ ATNEC 3526_ SSPTS 3531_ SATYQ 3536_ PSFAA 3541_ AVRSN 3546_ TGQKT 3551_ QPDVM 3556_ SQNAR 3561_ KLIQK 3566_ NLATS 3571_ ADTPP 3576_ STVPG 3581_ TGKSV 3586_ ACSPK 3591_ KAVRD 3596_ PKTGK 3601_ AVQER 3606_ NSYAV 3611_ SVWKR 3616_ VKAKL 3621_ EGRDV 3626_ DPNRR 3631_ MSVAE 3636_ QVDYV 3641_ IKEAT 3646_ NLDNL 3651_ AQLYE 3656_GWTAW
1: Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ