Ankyrin repeat and SOCS box protein 2 (ASB-2)
1_MATQI 6_ STRGS 11_ QCTIG 16_ QEEYS 21_ LYSSL 26_ SEDEL 31_ VQMAI 36_ EQSLA 41_ DKTRG 46_ PTTAE 51_ ATASA 56_ CTNRQ 61_ PAHFY 66_ PWTRS 71_ TAPPE 76_ SSPAR 81_ APMGL 86_ FQGVM 91_ QKYSS 96_ SLFKT 101_ SQLAP 106_ ADPLI 111_ KAIKD 116_ GDEEA 121_ LKTMI 126_ KEGKN 131_ LAEPN 136_ KEGWL 141_ PLHEA 146_ AYYGQ 151_ VGCLK 156_ VLQRA 161_ YPGTI 166_ DQRTL 171_ QEETA 176_ VYLAT 181_ CRGHL 186_ DCLLS 191_ LLQAG 196_ AEPDI 201_ SNKSR 206_ ETPLY 211_ KACER 216_ KNAEA 221_ VKILV 226_ QHNAD 231_ TNHRC 236_ NRGWT 241_ ALHES 246_ VSRND 251_ LEVMQ 256_ ILVSG 261_ GAKVE 266_ SKNAY 271_ GITPL 276_ FVAAQ 281_ SGQLE 286_ ALRFL 291_ AKYGA 296_ DINTQ 301_ ASDNA 306_ SALYE 311_ ACKNE 316_ HEEVV 321_ EFLLS 326_ QGADA 331_ NKTNK 336_ DGLLP 341_ LHIAS 346_ KKGNY 351_ RIVQM 356_ LLPVT 361_ SRTRI 366_ RRSGV 371_ SPLHL 376_ AAERN 381_ HDEVL 386_ EALLS 391_ ARFDV 396_ NTPLA 401_ PERAR 406_ LYEDR 411_ RSSAL 416_ YFAVV 421_ NNNVY 426_ ATELL 431_ LQHGA 436_ DPNRD 441_ VISPL 446_ LVAIR 451_ HGCLR 456_ TMQLL 461_ LDHGA 466_ NIDAY 471_ IATHP 476_ TAFPA 481_ TIMFA 486_ MKCLS 491_ LLKFL 496_ MDLGC 501_ DGEPC 506_ FSCLY 511_ GNGPH 516_ PPAPQ 521_ PSSRF 526_ NDAPA 531_ ADKEP 536_ SVVQF 541_ CEFVS 546_ APEVS 551_ RWAGP 556_ IIDVL 561_ LDYVG 566_ NVQLC 571_ SRLKE 576_ HIDSF 581_ EDWAV 586_ IKEKA 591_ EPPRP 596_ LAHLC 601_ RLRVR 606_ KAIGK 611_ YRIKL 616_ LDTLP 621_ LPGRL 626_IRYLK
1: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15590664, PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed:32179481). Specifically promotes the ubiquitination of SMAD9 and targets it for proteasomal degradation, leading to avoid excessive accumulation of SMAD9 (PubMed:34845242). Plays a role in the regulation of NK-cell migration by modulating protein levels of filamin A/FLNA via regulation of its ubiquitination and proteasome degradation (By similarity)
2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:19300455). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity)
3: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:21737450, PubMed:22916308, PubMed:24044920, PubMed:24052262). This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed:21737450). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed:22916308)