Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)
1_MAWQG 6_ LAAEF 11_ LQVPA 16_ VTRAY 21_ TAACV 26_ LTTAA 31_ VQLEL 36_ LSPFQ 41_ LYFNP 46_ HLVFR 51_ KFQVW 56_ RLVTN 61_ FLFFG 66_ PLGFS 71_ FFFNM 76_ LFVFR 81_ YCRML 86_ EEGSF 91_ RGRTA 96_ DFVFM 101_ FLFGG 106_ VLMTL 111_ LGLLG 116_ SLFFL 121_ GQALM 126_ AMLVY 131_ VWSRR 136_ SPRVR 141_ VNFFG 146_ LLTFQ 151_ APFLP 156_ WALMG 161_ FSLLL 166_ GNSIL 171_ VDLLG 176_ IAVGH 181_ IYYFL 186_ EDVFP 191_ NQPGG 196_ KRLLQ 201_ TPGFL 206_ KLLLD 211_ APAED 216_ PNYLP 221_ LPEEQ 226_PGPHL
1: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908)