Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1)
1_MEEKR 6_ RRARV 11_ QGAWA 16_ APVKS 21_ QAIAQ 26_ PATTA 31_ KSHLH 36_ QKPGQ 41_ TWKNK 46_ EHHLS 51_ DREFV 56_ FKEPQ 61_ QVVRR 66_ APEPR 71_ VIDRE 76_ GVYEI 81_ SLSPT 86_ GVSRV 91_ CLYPG 96_ FVDVK 101_ EADWI 106_ LEQLC 111_ QDVPW 116_ KQRTG 121_ IREDI 126_ TYQQP 131_ RLTAW 136_ YGELP 141_ YTYSR 146_ ITMEP 151_ NPHWH 156_ PVLRT 161_ LKNRI 166_ EENTG 171_ HTFNS 176_ LLCNL 181_ YRNEK 186_ DSVDW 191_ HSDDE 196_ PSLGR 201_ CPIIA 206_ SLSFG 211_ ATRTF 216_ EMRKK 221_ PPPEE 226_ NGDYT 231_ YVERV 236_ KIPLD 241_ HGTLL 246_ IMEGA 251_ TQADW 256_ QHRVP 261_ KEYHS 266_ REPRV 271_ NLTFR 276_ TVYPD 281_PRGAP
1: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA (PubMed:25797601). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:16858410, PubMed:26863196, PubMed:26863410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:16858410, PubMed:22055184)