Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)
1_MGSGP 6_ IDPKE 11_ LLKGL 16_ DSFLN 21_ RDGEV 26_ KSVDG 31_ ISKIF 36_ SLMKE 41_ ARKMV 46_ SRCTY 51_ LNILL 56_ QTRSP 61_ EILVK 66_ FIDVG 71_ GYKLL 76_ NNWLT 81_ YSKTT 86_ NNIPL 91_ LQQIL 96_ LTLQH 101_ LPLTV 106_ DHLKQ 111_ NNTAK 116_ LVKQL 121_ SKSSE 126_ DEELR 131_ KLASV 136_ LVSDW 141_ MAVIR 146_ SQSST 151_ QPAEK 156_ DKKKR 161_ KDEGK 166_ SRTTL 171_ PERPL 176_ TEVKA 181_ ETRAE 186_ EAPEK 191_ KREKP 196_ KSLRT 201_ TAPSH 206_ AKFRS 211_ TGLEL 216_ ETPSL 221_ VPVKK 226_ NASTV 231_ VVSDK 236_ YNLKP 241_ IPLKR 246_ QSNVA 251_ APGDA 256_ TPPAE 261_ KKYKP 266_ LNTTP 271_ NATKE 276_ IKVKI 281_ IPPQP 286_ MEGLG 291_ FLDAL 296_ NSAPV 301_ PGIKI 306_ KKKKK 311_ VLSPT 316_ AAKPS 321_ PFEGK 326_ TSTEP 331_ STAKP 336_ SSPEP 341_ APPSE 346_ AMDAD 351_ RPGTP 356_ VPPVE 361_ VPELM 366_ DTASL 371_ EPGAL 376_ DAKPV 381_ ESPGD 386_ PNQLT 391_ RKGRK 396_ RKSVT 401_ WPEEG 406_ KLREY 411_ FYFEL 416_ DETER 421_ VNVNK 426_ IKDFG 431_ EAAKR 436_ EILSD 441_ RHAFE 446_ TARRL 451_ SHDNM 456_ EEKVP 461_ WVCPR 466_ PLVLP 471_ SPLVT 476_ PGSNS 481_ QERYI 486_ QAERE 491_ KGILQ 496_ ELFLN 501_ KESPH 506_ EPDPE 511_ PYEPI 516_ PPKLI 521_ PLDEE 526_ CSMDE 531_ TPYVE 536_ TLEPG 541_ GSGGS 546_ PDGAG 551_ GSKLP 556_ PVLAN 561_ LMGSM 566_ GAGKG 571_ PQGPG 576_ GGGIN 581_ VQEIL 586_ TSIMG 591_ SPNSH 596_ PSEEL 601_ LKQPD 606_ YSDKI 611_ KQMLV 616_ PHGLL 621_ GPGPI 626_ ANGFP 631_ PGGPG 636_ GPKGM 641_ QHFPP 646_ GPGGP 651_ MPGPH 656_ GGPGG 661_ PVGPR 666_ LLGPP 671_ PPPRG 676_ GDPFW 681_ DGPGD 686_ PMRGG 691_ PMRGG 696_ PGPGP 701_ GPYHR 706_ GRGGR 711_ GGNEP 716_ PPPPP 721_ PFRGA 726_ RGGRS 731_ GGGPP 736_ NGRGG 741_ PGGGM 746_ VGGGG 751_ HRPHE 756_ GPGGG 761_ MGNSS 766_ GHRPH 771_ EGPGG 776_ GMGSG 781_ HRPHE 786_ GPGGS 791_ MGGGG 796_ GHRPH 801_ EGPGG 806_ GISGG 811_ SGHRP 816_ HEGPG 821_ GGMGA 826_ GGGHR 831_ PHEGP 836_ GGSMG 841_ GSGGH 846_ RPHEG 851_ PGHGG 856_ PHGHR 861_ PHDVP 866_ GHRGH 871_ DHRGP 876_ PPHEH 881_ RGHDG 886_ PGHGG 891_ GGHRG 896_ HDGGH 901_ SHGGD 906_ MSNRP 911_ VCRHF 916_ MMKGN 921_ CRYEN 926_ NCAFY 931_HPGVN
1: Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108)