Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)
1_MKKAE 6_ MGRFS 11_ ISPDE 16_ DSSSY 21_ SSNSD 26_ FNYSY 31_ PTKQA 36_ ALKSH 41_ YADVD 46_ PENQN 51_ FLLES 56_ NLGKK 61_ KYETE 66_ FHPGT 71_ TSFGM 76_ SVFNL 81_ SNAIV 86_ GSGIL 91_ GLSYA 96_ MANTG 101_ IALFI 106_ ILLTF 111_ VSIFS 116_ LYSVH 121_ LLLKT 126_ ANEGG 131_ SLLYE 136_ QLGYK 141_ AFGLV 146_ GKLAA 151_ SGSIT 156_ MQNIG 161_ AMSSY 166_ LFIVK 171_ YELPL 176_ VIQAL 181_ TNIED 186_ KTGLW 191_ YLNGN 196_ YLVLL 201_ VSLVV 206_ ILPLS 211_ LFRNL 216_ GYLGY 221_ TSGLS 226_ LLCMV 231_ FFLIV 236_ VICKK 241_ FQVPC 246_ PVEAA 251_ LIINE 256_ TINTT 261_ LTQPT 266_ ALVPA 271_ LSHNV 276_ TENDS 281_ CRPHY 286_ FIFNS 291_ QTVYA 296_ VPILI 301_ FSFVC 306_ HPAVL 311_ PIYEE 316_ LKDRS 321_ RRRMM 326_ NVSKI 331_ SFFAM 336_ FLMYL 341_ LAALF 346_ GYLTF 351_ YEHVE 356_ SELLH 361_ TYSSI 366_ LGTDI 371_ LLLIV 376_ RLAVL 381_ MAVTL 386_ TVPVV 391_ IFPIR 396_ SSVTH 401_ LLCAS 406_ KDFSW 411_ WRHSL 416_ ITVSI 421_ LAFTN 426_ LLVIF 431_ VPTIR 436_ DIFGF 441_ IGASA 446_ ASMLI 451_ FILPS 456_ AFYIK 461_ LVKKE 466_ PMKSV 471_ QKIGA 476_ LFFLL 481_ SGVLV 486_ MTGSM 491_ ALIVL 496_ DWVHN 501_APGGG
1: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity)