ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
1_MVGVL 6_ AMAAA 11_ AAPPP 16_ VKDCE 21_ IEPCK 26_ KRKKD 31_ DDTST 36_ CKTIT 41_ KYLSP 46_ LGKTR 51_ DRVFA 56_ PPKPS 61_ NILDY 66_ FRKTS 71_ PTNEK 76_ TQLGK 81_ ECKIK 86_ SPESV 91_ PVDSN 96_ KDCTT 101_ PLEMF 106_ SNVEF 111_ KKKRK 116_ RVNLS 121_ HQLNN 126_ IKTEN 131_ EAPIE 136_ ISSDD 141_ SKEDY 146_ SLNND 151_ FVESS 156_ TSVLR 161_ YKKQV 166_ EVLAE 171_ NIQDT 176_ KSQPN 181_ TMTSL 186_ QNSKK 191_ VNPKQ 196_ GTTKN 201_ DFKKL 206_ RKRKC 211_ RDVVD 216_ LSESL 221_ PLAEE 226_ LNLLK 231_ KDGKD 236_ TKQME 241_ NTTSH 246_ ANSRD 251_ NVTEA 256_ AQLND 261_ SIITV 266_ SYEEF 271_ LKSHK 276_ ENKVE 281_ EIPDS 286_ TMSIC 291_ VPSET 296_ VDEIV 301_ KSGYI 306_ SESEN 311_ SEISQ 316_ QVRFK 321_ TVTVL 326_ AQVHP 331_ IPPKK 336_ TGKIP 341_ RIFLK 346_ QKQFE 351_ MENSL 356_ SDPEN 361_ EQTVQ 366_ KRKSN 371_ VVIQE 376_ EELEL 381_ AVLEA 386_ GSSEA 391_ VKPKC 396_ TLEER 401_ QQFMK 406_ AFRQP 411_ ASDAL 416_ KNGVK 421_ KSSDK 426_ QKDLN 431_ EKCLY 436_ EVGRD 441_ DNSKK 446_ IMENS 451_ GIQMV 456_ SKNGN 461_ LQLHT 466_ DKGSF 471_ LKEKN 476_ KKLKK 481_ KNKKT 486_ LDTGA 491_ IPGKN 496_ REGNT 501_ QKKET 506_ TFFLK 511_ EKQYQ 516_ NRMSL 521_ RQRKT 526_ EFFKS 531_ STLFN 536_ NESLV 541_ YEDIA 546_ NDDLL 551_ KVSSL 556_ CNNNK 561_ LSRKT 566_ SIPVK 571_ DIKLT 576_ QSKAE 581_ SEASL 586_ LNVST 591_ PKSTR 596_ RSGRI 601_ SSTPT 606_ TETIR 611_ GIDSD 616_ DVQDN 621_ SQLKA 626_ STQKA 631_ ANLSE 636_ KHSLY 641_ TAELI 646_ TVPFD 651_ SESPI 656_ RMKFT 661_ RISTP 666_ KKSKK 671_ KSNKR 676_ SEKSE 681_ ATDGG 686_ FTSQI 691_ RKASN 696_ TSKNI 701_ SKAKQ 706_ LIEKA 711_ KALHI 716_ SRSKV 721_ TEEIA 726_ IPLRR 731_ SSRHQ 736_ TLPER 741_ KKLSE 746_ TEDSV 751_ IIIDS 756_ SPTAL 761_ KHPEK 766_ NQKKL 771_ QCLND 776_ VLGKK 781_ LNTST 786_ KNVPG 791_ KMKVA 796_ PLFLV 801_ RKAQK 806_ AADPV 811_ PSFDE 816_ SSQDT 821_ SEKSQ 826_ DCDVQ 831_ CKAKR 836_ DFLMS 841_ GLPDL 846_ LKRQI 851_ AKKAA 856_ ALDVY 861_ NAVST 866_ SFQRV 871_ VHVQQ 876_ KDDGC 881_ CLWHL 886_ KPPSC 891_ PLLTK 896_ FKELN 901_ TKVID 906_ LSKCG 911_ IALGE 916_ FSTLN 921_ SKLKS 926_ GNSAA 931_ VFMRT 936_ RKEFT 941_ EEVRN 946_ LLLEE 951_ IRWSN 956_ PEFSL 961_ KKYFP 966_ LLLKK 971_ QIEHQ 976_ VLSSE 981_ CHSKQ 986_ ELEAD 991_ VSHKE 996_ TKRKL 1001_ VEAEN 1006_ SKSKR 1011_ KKPNE 1016_ YSKNL 1021_ EKTNR 1026_ KSEEL 1031_ SKRNN 1036_ SSGIK 1041_ LDSSK 1046_ DSGTE 1051_ DMLWT 1056_ EKYQP 1061_ QTASE 1066_ LIGNE 1071_ LAIKK 1076_ LHSWL 1081_ KDWKR 1086_ RAELE 1091_ ERQNL 1096_ KGKRD 1101_ EKHED 1106_ FSGGI 1111_ DFKGS 1116_ SDDEE 1121_ ESRLC 1126_ NTVLI 1131_ TGPTG 1136_ VGKTA 1141_ AVYAC 1146_ AQELG 1151_ FKIFE 1156_ VNASS 1161_ QRSGR 1166_ QILSQ 1171_ LKEAT 1176_ QSHQV 1181_ DKQGV 1186_ NSQKP 1191_ CFFNS 1196_ YYIGK 1201_ SPKKI 1206_ SSPKK 1211_ VVTSP 1216_ RKVPP 1221_ PSPKS 1226_ SGPKR 1231_ ALPPK 1236_ TLANY 1241_ FKVSP 1246_ KPKNN 1251_ EEIGM 1256_ LLENN 1261_ KGIKN 1266_ SFEQK 1271_ QITQT 1276_ KSTNA 1281_ TNSNV 1286_ KDVGA 1291_ EEPSR 1296_ KNATS 1301_ LILFE 1306_ EVDVI 1311_ FDEDA 1316_ GFLNA 1321_ IKTFM 1326_ ATTKR 1331_ PVILT 1336_ TSDPT 1341_ FSLMF 1346_ DGCFE 1351_ EIKFS 1356_ TPSLL 1361_ NVASY 1366_ LQMIC 1371_ LTENF 1376_ RTDVK 1381_ DFVTL 1386_ LTANT 1391_ CDIRK 1396_ SILYL 1401_ QFWIR 1406_ SGGGV 1411_ LEERP 1416_ LTLYR 1421_ GNSRN 1426_ VQLVC 1431_ SEHGL 1436_ DNKIY 1441_ PKNTK 1446_ KKRVD 1451_ LPKCD 1456_ SGCAE 1461_ TLFGL 1466_ KNIFS 1471_ PSEDL 1476_ FSFLK 1481_ HKITM 1486_ KEEWH 1491_ KFIQL 1496_ LTEFQ 1501_ MRNVD 1506_ FLYSN 1511_ LEFIL 1516_ PLPVD 1521_ TIPET 1526_ KNFCG 1531_ PSVTV 1536_ DASAA 1541_ TKSMN 1546_ CLARK 1551_ HSERE 1556_ QPLKK 1561_ SQKKK 1566_ QKKTL 1571_ VILDD 1576_ SDLFD 1581_ TDLDF 1586_ PDQSI 1591_ SLSSV 1596_ SSSSN 1601_ AEESK 1606_ TGDEE 1611_ SKARD 1616_ KGNNP 1621_ ETKKS 1626_ IPCPP 1631_ KTTAG 1636_ KKCSA 1641_ LVSHC 1646_ LNSLS 1651_ EFMDN 1656_ MSFLD 1661_ ALLTD 1666_ VREQN 1671_ KYGRN 1676_ DFSWT 1681_ NGKVT 1686_ SGLCD 1691_ EFSLE 1696_ SNDGW 1701_ TSQSS 1706_ GELKA 1711_ AAEAL 1716_ SFTKC 1721_ SSAIS 1726_ KALET 1731_ LNSCK 1736_ KLGRD 1741_ PTNDL 1746_ TFYVS 1751_ QKRNN 1756_ VYFSQ 1761_ SAANL 1766_ DNAWK 1771_ RISVI 1776_ KSVFS 1781_ SRSLL 1786_ YVGNR 1791_ QASII 1796_ EYLPT 1801_ LRNIC 1806_ KTEKL 1811_ KEQGK 1816_ SKRRF 1821_ LHYFE 1826_ GIHLD 1831_ IPKET 1836_VNTLA
1: Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045)