Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9)
1_MEFAE 6_ LIKTP 11_ RVDNV 16_ VLHRP 21_ FYPAV 26_ EGTLC 31_ LTGHH 36_ LILSS 41_ RQDNT 46_ EELWL 51_ LHSNI 56_ DAIDK 61_ RFVGS 66_ LGTII 71_ IKCKD 76_ FRIIQ 81_ LDIPG 86_ MEECL 91_ NIASS 96_ IEALS 101_ TLDSI 106_ TLMYP 111_ FFYRP 116_ MFEVI 121_ EDGWH 126_ SFLPE 131_ QEFEL 136_ YSSAT 141_ SEWRL 146_ SYVNK 151_ EFAVC 156_ PSYPP 161_ IVTVP 166_ KSIDD 171_ EALRK 176_ VATFR 181_ HGGRF 186_ PVLSY 191_ YHKKN 196_ GMVIM 201_ RSGQP 206_ LTGTN 211_ GRRCK 216_ EDEKL 221_ INATL 226_ RAGKR 231_ GYIID 236_ TRSLN 241_ VAQQT 246_ RAKGG 251_ GFEQE 256_ AHYPQ 261_ WRRIH 266_ KSIER 271_ YHILQ 276_ ESLIK 281_ LVEAC 286_ NDQTH 291_ NMDRW 296_ LSKLE 301_ ASNWL 306_ THIKE 311_ ILTTA 316_ CLAAQ 321_ CIDRE 326_ GASIL 331_ IHGTE 336_ GTDST 341_ LQVTS 346_ LAQII 351_ LEPRS 356_ RTIRG 361_ FEALI 366_ EREWL 371_ QAGHP 376_ FQQRC 381_ AQSAY 386_ CNTKQ 391_ KWEAP 396_ VFLLF 401_ LDCVW 406_ QILRQ 411_ FPCSF 416_ EFNEN 421_ FLIML 426_ FEHAY 431_ ASQFG 436_ TFLGN 441_ NESER 446_ CKLKL 451_ QQKTM 456_ SLWSW 461_ VNQPS 466_ ELSKF 471_ TNPLF 476_ EANNL 481_ VIWPS 486_ VAPQS 491_ LPLWE 496_ GIFLR 501_ WNRSS 506_ KYLDE 511_ AYEEM 516_ VNIIE 521_ YNKEL 526_ QAKVN 531_ ILRRQ 536_ LAELE 541_TEDGM
1: Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970)