Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)
1_MPTTQ 6_ QSPQD 11_ EQEKL 16_ LDEAI 21_ QAVKV 26_ QSFQM 31_ KRCLD 36_ KNKLM 41_ DALKH 46_ ASNML 51_ GELRT 56_ SMLSP 61_ KSYYE 66_ LYMAI 71_ SDELH 76_ YLEVY 81_ LTDEF 86_ AKGRK 91_ VADLY 96_ ELVQY 101_ AGNII 106_ PRLYL 111_ LITVG 116_ VVYVK 121_ SFPQS 126_ RKDIL 131_ KDLVE 136_ MCRGV 141_ QHPLR 146_ GLFLR 151_ NYLLQ 156_ CTRNI 161_ LPDEG 166_ EPTDE 171_ ETTGD 176_ ISDSM 181_ DFVLL 186_ NFAEM 191_ NKLWV 196_ RMQHQ 201_ GHSRD 206_ REKRE 211_ RERQE 216_ LRILV 221_ GTNLV 226_ RLSQL 231_ EGVNV 236_ ERYKQ 241_ IVLTG 246_ ILEQV 251_ VNCRD 256_ ALAQE 261_ YLMEC 266_ IIQVF 271_ PDEFH 276_ LQTLN 281_ PFLRA 286_ CAELH 291_ QNVNV 296_ KNIII 301_ ALIDR 306_ LALFA 311_ HREDG 316_ PGIPA 321_ DIKLF 326_ DIFSQ 331_ QVATV 336_ IQSRQ 341_ DMPSE 346_ DVVSL 351_ QVSLI 356_ NLAMK 361_ CYPDR 366_ VDYVD 371_ KVLET 376_ TVEIF 381_ NKLNL 386_ EHIAT 391_ SSAVS 396_ KELTR 401_ LLKIP 406_ VDTYN 411_ NILTV 416_ LKLKH 421_ FHPLF 426_ EYFDY 431_ ESRKS 436_ MSCYV 441_ LSNVL 446_ DYNTE 451_ IVSQD 456_ QVDSI 461_ MNLVS 466_ TLIQD 471_ QPDQP 476_ VEDPD 481_ PEDFA 486_ DEQSL 491_ VGRFI 496_ HLLRS 501_ EDPDQ 506_ QYLIL 511_ NTARK 516_ HFGAG 521_ GNQRI 526_ RFTLP 531_ PLVFA 536_ AYQLA 541_ FRYKE 546_ NSKVD 551_ DKWEK 556_ KCQKI 561_ FSFAH 566_ QTISA 571_ LIKAE 576_ LAELP 581_ LRLFL 586_ QGALA 591_ AGEIG 596_ FENHE 601_ TVAYE 606_ FMSQA 611_ FSLYE 616_ DEISD 621_ SKAQL 626_ AAITL 631_ IIGTF 636_ ERMKC 641_ FSEEN 646_ HEPLR 651_ TQCAL 656_ AASKL 661_ LKKPD 666_ QGRAV 671_ STCAH 676_ LFWSG 681_ RNTDK 686_ NGEEL 691_ HGGKR 696_ VMECL 701_ KKALK 706_ IANQC 711_ MDPSL 716_ QVQLF 721_ IEILN 726_ RYIYF 731_ YEKEN 736_ DAVTI 741_ QVLNQ 746_ LIQKI 751_ REDLP 756_ NLESS 761_ EETEQ 766_ INKHF 771_ HNTLE 776_ HLRLR 781_ RESPE 786_ SEGPI 791_YEGLI
1: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837)
2: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus