Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase)
1_MNNQK 6_ VVAVL 11_ LQECK 16_ QVLDQ 21_ LLLEA 26_ PDVSE 31_ EDKSE 36_ DQRCR 41_ ALLPS 46_ ELRTL 51_ IQEAK 56_ EMKWP 61_ FVPEK 66_ WQYKQ 71_ AVGPE 76_ DKTNL 81_ KDVIG 86_ AGLQQ 91_ LLASL 96_ RASIL 101_ ARDCA 106_ AAAAI 111_ VFLVD 116_ RFLYG 121_ LDVSG 126_ KLLQV 131_ AKGLH 136_ KLQPA 141_ TPIAP 146_ QVVIR 151_ QARIS 156_ VNSGK 161_ LLKAE 166_ YILSS 171_ LISNN 176_ GATGT 181_ WLYRN 186_ ESDKV 191_ LVQSV 196_ CIQIR 201_ GQILQ 206_ KLGMW 211_ YEAAE 216_ LIWAS 221_ IVGYL 226_ ALPQP 231_ DKKGL 236_ STSLG 241_ ILADI 246_ FVSMS 251_ KNDYE 256_ KFKNN 261_ PQINL 266_ SLLKE 271_ FDHHL 276_ LSAAE 281_ ACKLA 286_ AAFSA 291_ YTPLF 296_ VLTAV 301_ NIRGT 306_ CLLSY 311_ SSSND 316_ CPPEL 321_ KNLHL 326_ CEAKE 331_ AFEIG 336_ LLTKR 341_ DDEPV 346_ TGKQE 351_ LHSFV 356_ KAAFG 361_ LTTVH 366_ RRLHG 371_ ETGTV 376_ HAASQ 381_ LCKEA 386_ MGKLY 391_ NFSTS 396_ SRSQD 401_ REALS 406_ QEVMS 411_ VIAQV 416_ KEHLQ 421_ VQSFS 426_ NVDDR 431_ SYVPE 436_ SFECR 441_ LDKLI 446_ LHGQG 451_ DFQKI 456_ LDTYS 461_ QHHTS 466_ VCEVF 471_ ESDCG 476_ NNKNE 481_ QKDAK 486_ TGVCI 491_ TALKT 496_ EIKNI 501_ DTVST 506_ TQEKP 511_ HCQRD 516_ TGISS 521_ SLMGK 526_ NVQRE 531_ LRRGG 536_ RRNWT 541_ HSDAF 546_ RVSLD 551_ QDVET 556_ ETEPS 561_ DYSNG 566_ EGAVF 571_ NKSLS 576_ GSQTS 581_ SAWSN 586_ LSGFS 591_ SSASW 596_ EEVNY 601_ HVDDR 606_ SARKE 611_ PGKEH 616_ LVDTQ 621_ CSTAL 626_ SEELE 631_ NDREG 636_ RAMHS 641_ LHSQL 646_ HDLSL 651_ QEPNN 656_ DNLEP 661_ SQNQP 666_ QQQMP 671_ LTPFS 676_ PHNTP 681_ GIFLA 686_ PGAGL 691_ LEGAP 696_ EGIQE 701_ VRNMG 706_ PRNTS 711_ AHSRP 716_ SYRSA 721_ SWSSD 726_ SGRPK 731_ NMGTH 736_ PSVQK 741_ EEAFE 746_ IIVEF 751_ PETNC 756_ DVKDR 761_ QGKEQ 766_ GEEIS 771_ ERGAG 776_ PTFKA 781_ SPSWV 786_ DPEGE 791_ TAEST 796_ EDAPL 801_ DFHRV 806_ LHNSL 811_ GNISM 816_ LPCSS 821_ FTPNW 826_ PVQNP 831_ DSRKS 836_ GGPVA 841_ EQGID 846_ PDAST 851_ VDEEG 856_ QLLDS 861_ MDVPC 866_ TNGHG 871_ SHRLC 876_ ILRQP 881_ PGQRA 886_ ETPNS 891_ SVSGN 896_ ILFPV 901_ LSEDC 906_ TTTEE 911_ GNQPG 916_ NMLNC 921_ SQNSS 926_ SSSVW 931_ WLKSP 936_ AFSSG 941_ SSEGD 946_ SPWSY 951_ LNSSG 956_ SSWVS 961_ LPGKM 966_ RKEIL 971_ EARTL 976_ QPDDF 981_ EKLLA 986_ GVRHD 991_ WLFQR 996_ LENTG 1001_ VFKPS 1006_ QLHRA 1011_ HSALL 1016_ LKYSK 1021_ KSELW 1026_ TAQET 1031_ IVYLG 1036_ DYLTV 1041_ KKKGR 1046_ QRNAF 1051_ WVHHL 1056_ HQEEI 1061_ LGRYV 1066_ GKDYK 1071_ EQKGL 1076_ WHHFT 1081_ DVERQ 1086_ MTAQH 1091_ YVTEF 1096_ NKRLY 1101_ EQNIP 1106_ TQIFY 1111_ IPSTI 1116_ LLILE 1121_ DKTIK 1126_ GCISV 1131_ EPYIL 1136_ GEFVK 1141_ LSNNT 1146_ KVVKT 1151_ EYKAT 1156_ EYGLA 1161_ YGHFS 1166_ YEFSN 1171_ HRDVV 1176_ VDLQG 1181_ WVTGN 1186_ GKGLI 1191_ YLTDP 1196_ QIHSV 1201_ DQKVF 1206_ TTNFG 1211_ KRGIF 1216_ YFFNN 1221_ QHVEC 1226_ NEICH 1231_ RLSLT 1236_RPSME
1: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28222186, PubMed:28877472, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). May play a role in ciliogenesis (PubMed:30967659)