Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B)
1_MADGD 6_ SGSER 11_ GGGGG 16_ PCGFQ 21_ PASRG 26_ GGEQE 31_ TQELA 36_ SKRLD 41_ IQNKR 46_ FYLDV 51_ KQNAK 56_ GRFLK 61_ IAEVG 66_ AGGSK 71_ SRLTL 76_ SMAVA 81_ AEFRD 86_ SLGDF 91_ IEHYA 96_ QLGPS 101_ SPEQL 106_ AAGAE 111_ EGGGP 116_ RRALK 121_ SEFLV 126_ RENRK 131_ YYLDL 136_ KENQR 141_ GRFLR 146_ IRQTV 151_ NRGGG 156_ GFGAG 161_ PGPGG 166_ LQSGQ 171_ TIALP 176_ AQGLI 181_ EFRDA 186_ LAKLI 191_ DDYGG 196_ EDDEL 201_ AGGPG 206_ GGAGG 211_ PGGGL 216_ YGELP 221_ EGTSI 226_ TVDSK 231_ RFFFD 236_ VGCNK 241_ YGVFL 246_ RVSEV 251_ KPSYR 256_ NAITV 261_ PFKAW 266_ GKFGG 271_ AFCRY 276_ ADEMK 281_ EIQER 286_ QRDKL 291_ YERRG 296_ GGSGG 301_ GEESE 306_GEEVD
1: Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity)