Homeobox protein ARX (Aristaless-related homeobox)
1_MSNQY 6_ QEEGC 11_ SERPE 16_ CKSKS 21_ PTLLS 26_ SYCID 31_ SILGR 36_ RSPCK 41_ MRLLG 46_ AAQSL 51_ PAPLT 56_ SRADP 61_ EKAVQ 66_ GSPKS 71_ SSAPF 76_ EAELH 81_ LPPKL 86_ RRLYG 91_ PGGGR 96_ LLQGA 101_ AAAAA 106_ AAAAA 111_ AAAAA 116_ TATAG 121_ PRGEA 126_ PPPPP 131_ PTARP 136_ GERPD 141_ GAGAA 146_ AAAAA 151_ AAAAA 156_ WDTLK 161_ ISQAP 166_ QVSIS 171_ RSKSY 176_ RENGA 181_ PFVPP 186_ PPALD 191_ ELGGP 196_ GGVTH 201_ PEERL 206_ GVAGG 211_ PGSAP 216_ AAGGG 221_ TGTED 226_ DEEEL 231_ LEDEE 236_ DEDEE 241_ EELLE 246_ DDEEE 251_ LLEDD 256_ ARALL 261_ KEPRR 266_ CPVAA 271_ TGAVA 276_ AAAAA 281_ AVATE 286_ GGELS 291_ PKEEL 296_ LLHPE 301_ DAEGK 306_ DGEDS 311_ VCLSA 316_ GSDSE 321_ EGLLK 326_ RKQRR 331_ YRTTF 336_ TSYQL 341_ EELER 346_ AFQKT 351_ HYPDV 356_ FTREE 361_ LAMRL 366_ DLTEA 371_ RVQVW 376_ FQNRR 381_ AKWRK 386_ REKAG 391_ AQTHP 396_ PGLPF 401_ PGPLS 406_ ATHPL 411_ SPYLD 416_ ASPFP 421_ PHHPA 426_ LDSAW 431_ TAAAA 436_ AAAAA 441_ FPSLP 446_ PPPGS 451_ ASLPP 456_ SGAPL 461_ GLSTF 466_ LGAAV 471_ FRHPA 476_ FISPA 481_ FGRLF 486_ STMAP 491_ LTSAS 496_ TAAAL 501_ LRQPT 506_ PAVEG 511_ AVASG 516_ ALADP 521_ ATAAA 526_ DRRAS 531_ SIAAL 536_ RLKAK 541_ EHAAQ 546_ LTQLN 551_ ILPGT 556_STGKE
1: Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity)