Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7)
1_MSQKS 6_ WIEST 11_ LTKRE 16_ CVYII 21_ PSSKD 26_ PHRCL 31_ PGCQI 36_ CQQLV 41_ RCFCG 46_ RLVKQ 51_ HACFT 56_ ASLAM 61_ KYSDV 66_ KLGDH 71_ FNQAI 76_ EEWSV 81_ EKHTE 86_ QSPTD 91_ AYGVI 96_ NFQGG 101_ SHSYR 106_ AKYVR 111_ LSYDT 116_ KPEVI 121_ LQLLL 126_ KEWQM 131_ ELPKL 136_ VISVH 141_ GGMQK 146_ FELHP 151_ RIKQL 156_ LGKGL 161_ IKAAV 166_ TTGAW 171_ ILTGG 176_ VNTGV 181_ AKHVG 186_ DALKE 191_ HASRS 196_ SRKIC 201_ TIGIA 206_ PWGVI 211_ ENRND 216_ LVGRD 221_ VVAPY 226_ QTLLN 231_ PLSKL 236_ NVLNN 241_ LHSHF 246_ ILVDD 251_ GTVGK 256_ YGAEV 261_ RLRRE 266_ LEKTI 271_ NQQRI 276_ HARIG 281_ QGVPV 286_ VALIF 291_ EGGPN 296_ VILTV 301_ LEYLQ 306_ ESPPV 311_ PVVVC 316_ EGTGR 321_ AADLL 326_ AYIHK 331_ QTEEG 336_ GNLPD 341_ AAEPD 346_ IISTI 351_ KKTFN 356_ FGQNE 361_ ALHLF 366_ QTLME 371_ CMKRK 376_ ELITV 381_ FHIGS 386_ DEHQD 391_ IDVAI 396_ LTALL 401_ KGTNA 406_ SAFDQ 411_ LILTL 416_ AWDRV 421_ DIAKN 426_ HVFVY 431_ GQQWL 436_ VGSLE 441_ QAMLD 446_ ALVMD 451_ RVAFV 456_ KLLIE 461_ NGVSM 466_ HKFLT 471_ IPRLE 476_ ELYNT 481_ KQGPT 486_ NPMLF 491_ HLVRD 496_ VKQGN 501_ LPPGY 506_ KITLI 511_ DIGLV 516_ IEYLM 521_ GGTYR 526_ CTYTR 531_ KRFRL 536_ IYNSL 541_ GGNNR 546_ RSGRN 551_ TSSST 556_ PQLRK 561_ SHESF 566_ GNRAD 571_ KKEKM 576_ RHNHF 581_ IKTAQ 586_ PYRPK 591_ IDTVM 596_ EEGKK 601_ KRTKD 606_ EIVDI 611_ DDPET 616_ KRFPY 621_ PLNEL 626_ LIWAC 631_ LMKRQ 636_ VMARF 641_ LWQHG 646_ EESMA 651_ KALVA 656_ CKIYR 661_ SMAYE 666_ AKQSD 671_ LVDDT 676_ SEELK 681_ QYSND 686_ FGQLA 691_ VELLE 696_ QSFRQ 701_ DETMA 706_ MKLLT 711_ YELKN 716_ WSNST 721_ CLKLA 726_ VSSRL 731_ RPFVA 736_ HTCTQ 741_ MLLSD 746_ MWMGR 751_ LNMRK 756_ NSWYK 761_ VILSI 766_ LVPPA 771_ ILLLE 776_ YKTKA 781_ EMSHI 786_ PQSQD 791_ AHQMT 796_ MDDSE 801_ NNFQN 806_ ITEEI 811_ PMEVF 816_ KEVRI 821_ LDSNE 826_ GKNEM 831_ EIQMK 836_ SKKLP 841_ ITRKF 846_ YAFYH 851_ APIVK 856_ FWFNT 861_ LAYLG 866_ FLMLY 871_ TFVVL 876_ VQMEQ 881_ LPSVQ 886_ EWIVI 891_ AYIFT 896_ YAIEK 901_ VREIF 906_ MSEAG 911_ KVNQK 916_ IKVWF 921_ SDYFN 926_ ISDTI 931_ AIISF 936_ FIGFG 941_ LRFGA 946_ KWNFA 951_ NAYDN 956_ HVFVA 961_ GRLIY 966_ CLNII 971_ FWYVR 976_ LLDFL 981_ AVNQQ 986_ AGPYV 991_ MMIGK 996_ MVANM 1001_ FYIVV 1006_ IMALV 1011_ LLSFG 1016_ VPRKA 1021_ ILYPH 1026_ EAPSW 1031_ TLAKD 1036_ IVFHP 1041_ YWMIF 1046_ GEVYA 1051_ YEIDV 1056_ CANDS 1061_ VIPQI 1066_ CGPGT 1071_ WLTPF 1076_ LQAVY 1081_ LFVQY 1086_ IIMVN 1091_ LLIAF 1096_ FNNVY 1101_ LQVKA 1106_ ISNIV 1111_ WKYQR 1116_ YHFIM 1121_ AYHEK 1126_ PVLPP 1131_ PLIIL 1136_ SHIVS 1141_ LFCCI 1146_ CKRRK 1151_ KDKTS 1156_ DGPKL 1161_ FLTEE 1166_ DQKKL 1171_ HDFEE 1176_ QCVEM 1181_ YFNEK 1186_ DDKFH 1191_ SGSEE 1196_ RIRVT 1201_ FERVE 1206_ QMCIQ 1211_ IKEVG 1216_ DRVNY 1221_ IKRSL 1226_ QSLDS 1231_ QIGHL 1236_ QDLSA 1241_ LTVDT 1246_ LKTLT 1251_ AQKAS 1256_ EASKV 1261_ HNEIT 1266_ RELSI 1271_ SKHLA 1276_ QNLID 1281_ DGPVR 1286_ PSVWK 1291_ KHGVV 1296_ NTLSS 1301_ SLPQG 1306_ DLESN 1311_ NPFHC 1316_ NILMK 1321_ DDKDP 1326_ QCNIF 1331_ GQDLP 1336_ AVPQR 1341_ KEFNF 1346_ PEAGS 1351_ SSGAL 1356_ FPSAV 1361_ SPPEL 1366_ RQRLH 1371_ GVELL 1376_ KIFNK 1381_ NQKLG 1386_ SSSTS 1391_ IPHLS 1396_ SPPTK 1401_ FFVST 1406_ PSQPS 1411_ CKSHL 1416_ ETGTK 1421_ DQETV 1426_ CSKAT 1431_ EGDNT 1436_ EFGAF 1441_ VGHRD 1446_ SMDLQ 1451_ RFKET 1456_ SNKIK 1461_ ILSNN 1466_ NTSEN 1471_ TLKRV 1476_ SSLAG 1481_ FTDCH 1486_ RTSIP 1491_ VHSKQ 1496_ AEKIS 1501_ RRPST 1506_ EDTHE 1511_ VDSKA 1516_ ALIPD 1521_ WLQDR 1526_ PSNRE 1531_ MPSEE 1536_ GTLNG 1541_ LTSPF 1546_ KPAMD 1551_ TNYYY 1556_ SAVER 1561_ NNLMR 1566_ LSQSI 1571_ PFTPV 1576_ PPRGE 1581_ PVTVY 1586_ RLEES 1591_ SPNIL 1596_ NNSMS 1601_ SWSQL 1606_ GLCAK 1611_ IEFLS 1616_ KEEMG 1621_ GGLRR 1626_ AVKVQ 1631_ CTWSE 1636_ HDILK 1641_ SGHLY 1646_ IIKSF 1651_ LPEVV 1656_ NTWSS 1661_ IYKED 1666_ TVLHL 1671_ CLREI 1676_ QQQRA 1681_ AQKLT 1686_ FAFNQ 1691_ MKPKS 1696_ IPYSP 1701_ RFLEV 1706_ FLLYC 1711_ HSAGQ 1716_ WFAVE 1721_ ECMTG 1726_ EFRKY 1731_ NNNNG 1736_ DEIIP 1741_ TNTLE 1746_ EIMLA 1751_ FSHWT 1756_ YEYTR 1761_ GELLV 1766_ LDLQG 1771_ VGENL 1776_ TDPSV 1781_ IKAEE 1786_ KRSCD 1791_ MVFGP 1796_ ANLGE 1801_ DAIKN 1806_ FRAKH 1811_ HCNSC 1816_ CRKLK 1821_ LPDLK 1826_ RNDYT 1831_ PDKII 1836_ FPQDE 1841_ PSDLN 1846_ LQPGN 1851_ STKES 1856_ESTNS
1: Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644)
2: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling
3: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development