PHD finger protein 12 (PHD factor 1) (Pf1)
1_MWEKM 6_ ETKTI 11_ VYDLD 16_ TSGGL 21_ MEQIQ 26_ ALLAP 31_ PKTDE 36_ AEKRS 41_ RKPEK 46_ EPRRS 51_ GRATN 56_ HDSCD 61_ SCKEG 66_ GDLLC 71_ CDHCP 76_ AAFHL 81_ QCCNP 86_ PLSEE 91_ MLPPG 96_ EWMCH 101_ RCTVR 106_ RKKRE 111_ QKKEL 116_ GHVNG 121_ LVDKS 126_ GKRTT 131_ SPSSD 136_ TDLLD 141_ RSASK 146_ TELKA 151_ IAHAR 156_ ILERR 161_ ASRPG 166_ TPTSS 171_ ASTET 176_ PTSEQ 181_ NDVDE 186_ DIIDV 191_ DEEPV 196_ AAEPD 201_ YVQPQ 206_ LRRPF 211_ ELLIA 216_ AAMER 221_ NPTQF 226_ QLPNE 231_ LTCTT 236_ ALPGS 241_ SKRRR 246_ KEETT 251_ GKNVK 256_ KTQHE 261_ LDHNG 266_ LVPLP 271_ VKVCF 276_ TCNRS 281_ CRVAP 286_ LIQCD 291_ YCPLL 296_ FHMDC 301_ LEPPL 306_ TAMPL 311_ GRWMC 316_ PNHIE 321_ HVVLN 326_ QKNMT 331_ LSNRC 336_ QVFDR 341_ FQDTV 346_ SQHVV 351_ KVDFL 356_ NRIHK 361_ KHPPN 366_ RRVLQ 371_ SVKRR 376_ SLKVP 381_ DAIKS 386_ QYQFP 391_ PPLIA 396_ PAAIR 401_ DGELI 406_ CNGIP 411_ EESQM 416_ HLLNS 421_ EHLAT 426_ QAEQQ 431_ EWLCS 436_ VVALQ 441_ CSILK 446_ HLSAK 451_ QMPSH 456_ WDSEQ 461_ TEKAD 466_ IKPVI 471_ VTDSS 476_ VTTSL 481_ QTADK 486_ TPTPS 491_ HYPLS 496_ CPSGI 501_ STQNS 506_ LSCSP 511_ PHQSP 516_ ALEDI 521_ GCSSC 526_ AEKSK 531_ KTPCG 536_ TANGP 541_ VNTEV 546_ KANGP 551_ HLYSS 556_ PTDST 561_ DPRRL 566_ PGANT 571_ PLPGL 576_ SHRQG 581_ WPRPL 586_ TPPAA 591_ GGLQN 596_ HTVGI 601_ IVKTE 606_ NATGP 611_ SSCPQ 616_ RSLVP 621_ VPSLP 626_ PSIPS 631_ SCASI 636_ ENTST 641_ LQRKT 646_ VQSQI 651_ GPPLT 656_ DSRPL 661_ GSPPN 666_ ATRVL 671_ TPPQA 676_ AGDGI 681_ LATTA 686_ NQRFS 691_ SPAPS 696_ SDGKV 701_ SPGTL 706_ SIGSA 711_ LTVPS 716_ FPANS 721_ TAMVD 726_ LTNSL 731_ RAFMD 736_ VNGEI 741_ EINML 746_ DEKLI 751_ KFLAL 756_ QRIHQ 761_ LFPSR 766_ VQPSP 771_ GSVGT 776_ HQLAS 781_ GGHHI 786_ EVQRK 791_ EVQAR 796_ AVFYP 801_ LLGLG 806_ GAVNM 811_ CYRTL 816_ YIGTG 821_ ADMDV 826_ CLTNY 831_ GHCNY 836_ VSGKH 841_ ACIFY 846_ DENTK 851_ HYELL 856_ NYSEH 861_ GTTVD 866_ NVLYS 871_ CDFSE 876_ KTPPT 881_ PPSSI 886_ VAKVQ 891_ SVIRR 896_ RRHQK 901_ QDEEP 906_ SEEAA 911_ MMSSQ 916_ AQGPQ 921_ RRPCN 926_ CKASS 931_ SSLIG 936_ GSGAG 941_ WEGTA 946_ LLHHG 951_ SYIKL 956_ GCLQF 961_ VFSIT 966_ EFATK 971_ QPKGD 976_ ASLLQ 981_ DGVLA 986_ EKLSL 991_ KPHQG 996_PVLRS
1: Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity)