Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
1_MWRVK 6_ KLSLS 11_ LSPSP 16_ QTGKP 21_ SMRTP 26_ LRELT 31_ LQPGA 36_ LTNSG 41_ KRSPA 46_ CSSLT 51_ PSLCK 56_ LGLQE 61_ GSNNS 66_ SPVDF 71_ VNNKR 76_ TDLSS 81_ EHFSH 86_ SSKWL 91_ ETCQH 96_ ESDEQ 101_ PLDPI 106_ PQISS 111_ TPKTS 116_ EEAVD 121_ PLGNY 126_ MVKTI 131_ VLVPS 136_ PLGQQ 141_ QDMIF 146_ EARLD 151_ TMAET 156_ NSISL 161_ NGPLR 166_ TDDLV 171_ REEVA 176_ PCMGD 181_ RFSEV 186_ AAVSE 191_ KPIFQ 196_ ESPSH 201_ LLEES 206_ PPNPC 211_ SEQLH 216_ CSKES 221_ LSSRT 226_ EAVRE 231_ DLVPS 236_ ESNAF 241_ LPSSV 246_ LWLSP 251_ STALA 256_ ADFRV 261_ NHVDP 266_ EEEIV 271_ EHGAM 276_ EEREM 281_ RFPTH 286_ PKESE 291_ TEDQA 296_ LVSSV 301_ EDILS 306_ TCLTP 311_ NLVEM 316_ ESQEA 321_ PGPAV 326_ EDVGR 331_ ILGSD 336_ TESWM 341_ SPLAW 346_ LEKGV 351_ NTSVM 356_ LENLR 361_ QSLSL 366_ PSMLR 371_ DAAIG 376_ TTPFS 381_ TCSVG 386_ TWFTP 391_ SAPQE 396_ KSTNT 401_ SQTGL 406_ VGTKH 411_ STSET 416_ EQLLC 421_ GRPPD 426_ LTALS 431_ RHDLE 436_ DNLLS 441_ SLVIL 446_ EVLSR 451_ QLRDW 456_ KSQLA 461_ VPHPE 466_ TQDSS 471_ TQTDT 476_ SHSGI 481_ TNKLQ 486_ HLKES 491_ HEMGQ 496_ ALQQA 501_ RNVMQ 506_ SWVLI 511_ SKELI 516_ SLLHL 521_ SLLHL 526_ EEDKT 531_ TVSQE 536_ SRRAE 541_ TLVCC 546_ CFDLL 551_ KKLRA 556_ KLQSL 561_ KAERE 566_ EARHR 571_ EEMAL 576_ RGKDA 581_ AEIVL 586_ EAFCA 591_ HASQR 596_ ISQLE 601_ QDLAS 606_ MREFR 611_ GLLKD 616_ AQTQL 621_ VGLHA 626_ KQEEL 631_ VQQTV 636_ SLTST 641_ LQQDW 646_ RSMQL 651_ DYTTW 656_ TALLS 661_ RSRQL 666_ TEKLT 671_ VKSQQ 676_ ALQER 681_ DVAIE 686_ EKQEV 691_ SRVLE 696_ QVSAQ 701_ LEECK 706_ GQTEQ 711_ LELEN 716_ SRLAT 721_ DLRAQ 726_ LQILA 731_ NMDSQ 736_ LKELQ 741_ SQHTH 746_ CAQDL 751_ AMKDE 756_ LLCQL 761_ TQSNE 766_ EQAAQ 771_ WQKEE 776_ MALKH 781_ MQAEL 786_ QQQQA 791_ VLAKE 796_ VRDLK 801_ ETLEF 806_ ADQEN 811_ QVAHL 816_ ELGQV 821_ ECQLK 826_ TTLEV 831_ LRERS 836_ LQCEN 841_ LKDTV 846_ ENLTA 851_ KLAST 856_ IADNQ 861_ EQDLE 866_ KTRQY 871_ SQKLG 876_ LLTEQ 881_ LQSLT 886_ LFLQT 891_ KLKEK 896_ TEQET 901_ LLLST 906_ ACPPT 911_ QEHPL 916_ PNDRT 921_ FLGSI 926_ LTAVA 931_ DEEPE 936_ STPVP 941_ LLGSD 946_ KSAFT 951_ RVASM 956_ VSLQP 961_ AETPG 966_ MEESL 971_ AEMSI 976_ MTTEL 981_ QSLCS 986_ LLQES 991_ KEEAI 996_ RTLQR 1001_ KICEL 1006_ QARLQ 1011_ AQEEQ 1016_ HQEVQ 1021_ KAKEA 1026_ DIEKL 1031_ NQALC 1036_ LRYKN 1041_ EKELQ 1046_ EVIQQ 1051_ QNEKI 1056_ LEQID 1061_ KSGEL 1066_ ISLRE 1071_ EVTHL 1076_ TRSLR 1081_ RAETE 1086_ TKVLQ 1091_ EALAG 1096_ QLDSN 1101_ CQPMA 1106_ TNWIQ 1111_ EKVWL 1116_ SQEVD 1121_ KLRVM 1126_ FLEMK 1131_ NEKEK 1136_ LMIKF 1141_ QSHRN 1146_ ILEEN 1151_ LRRSD 1156_ KELEK 1161_ LDDIV 1166_ QHIYK 1171_ TLLSI 1176_ PEVVR 1181_ GCKEL 1186_QGLLE
1: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457)