Pannexin-1
1_MAIAQ 6_ LATEY 11_ VFSDF 16_ LLKEP 21_ TEPKF 26_ KGLRL 31_ ELAVD 36_ KMVTC 41_ IAVGL 46_ PLLLI 51_ SLAFA 56_ QEISI 61_ GTQIS 66_ CFSPS 71_ SFSWR 76_ QAAFV 81_ DSYCW 86_ AAVQQ 91_ KNSLQ 96_ SESGN 101_ LPLWL 106_ HKFFP 111_ YILLL 116_ FAILL 121_ YLPPL 126_ FWRFA 131_ AAPHI 136_ CSDLK 141_ FIMEE 146_ LDKVY 151_ NRAIK 156_ AAKSA 161_ RDLDM 166_ RDGAC 171_ SVPGV 176_ TENLG 181_ QSLWE 186_ VSESH 191_ FKYPI 196_ VEQYL 201_ KTKKN 206_ SNNLI 211_ IKYIS 216_ CRLLT 221_ LIIIL 226_ LACIY 231_ LGYYF 236_ SLSSL 241_ SDEFV 246_ CSIKS 251_ GILRN 256_ DSTVP 261_ DQFQC 266_ KLIAV 271_ GIFQL 276_ LSVIN 281_ LVVYV 286_ LLAPV 291_ VVYTL 296_ FVPFR 301_ QKTDV 306_ LKVYE 311_ ILPTF 316_ DVLHF 321_ KSEGY 326_ NDLSL 331_ YNLFL 336_ EENIS 341_ EVKSY 346_ KCLKV 351_ LENIK 356_ SSGQG 361_ IDPML 366_ LLTNL 371_ GMIKM 376_ DVVDG 381_ KTPMS 386_ AEMRE 391_ EQGNQ 396_ TAELQ 401_ GMNID 406_ SETKA 411_ NNGEK 416_ NARQR 421_LLDSS
1: Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669)
2: During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells