Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)
1_MAQTL 6_ QMEIP 11_ NFGNS 16_ ILECL 21_ NEQRL 26_ QGLYC 31_ DVSVV 36_ VKGHA 41_ FKAHR 46_ AVLAA 51_ SSSYF 56_ RDLFN 61_ NSRSA 66_ VVELP 71_ AAVQP 76_ QSFQQ 81_ ILSFC 86_ YTGRL 91_ SMNVG 96_ DQFLL 101_ MYTAG 106_ FLQIQ 111_ EIMEK 116_ GTEFF 121_ LKVSS 126_ PSCDS 131_ QGLHA 136_ EEAPS 141_ SEPQS 146_ PVAQT 151_ SGWPA 156_ CSTPL 161_ PLVSR 166_ VKTEQ 171_ QESDS 176_ VQCMP 181_ VAKRL 186_ WDSGQ 191_ KEAGG 196_ GGNGS 201_ RKMAK 206_ FSTPD 211_ LAANR 216_ PHQPP 221_ PPQQA 226_ PVVAA 231_ AQPAV 236_ AAGAG 241_ QPAGG 246_ VAAAG 251_ GVVSG 256_ PSTSE 261_ RTSPG 266_ TSSAY 271_ TSDSP 276_ GSYHN 281_ EEDEE 286_ EDGGE 291_ EGMDE 296_ QYRQI 301_ CNMYT 306_ MYSMM 311_ NVGQT 316_ AEKVE 321_ ALPEQ 326_ VAPES 331_ RNRIR 336_ VRQDL 341_ ASLPA 346_ ELINQ 351_ IGNRC 356_ HPKLY 361_ DEGDP 366_ SEKLE 371_ LVTGT 376_ NVYIT 381_ RAQLM 386_ NCHVS 391_ AGTRH 396_ KVLLR 401_ RLLAS 406_ FFDRN 411_ TLANS 416_ CGTGI 421_ RSSTN 426_ DPRRK 431_ PLDSR 436_ VLHAV 441_ KYYCQ 446_ NFAPN 451_ FKESE 456_ MNAIA 461_ ADMCT 466_ NARRV 471_ VRKSW 476_ MPKVK 481_ VLKAE 486_ DDAYT 491_ TFISE 496_ TGKIE 501_ PDMMG 506_ VEHGF 511_ ETASH 516_ EGEAG 521_PSAEA
1: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines