Sorting nexin-18 (SH3 and PX domain-containing protein 3B)
1_MALRA 6_ RALYD 11_ FRSEN 16_ PGEIS 21_ LREHE 26_ VLSLC 31_ SEQDI 36_ EGWLE 41_ GVNSR 46_ GDRGL 51_ FPASY 56_ VQVIR 61_ APEPG 66_ PAGDG 71_ GPGAP 76_ ARYAN 81_ VPPGG 86_ FEPLP 91_ VAPPA 96_ SFKPP 101_ PDAFQ 106_ ALLQP 111_ QQAPP 116_ PSTFQ 121_ PPGAG 126_ FPYGG 131_ GALQP 136_ SPQQL 141_ YGGYQ 146_ ASQGS 151_ DDDWD 156_ DEWDD 161_ SSTVA 166_ DEPGA 171_ LGSGA 176_ YPDLD 181_ GSSSA 186_ GVGAA 191_ GRYRL 196_ STRSD 201_ LSLGS 206_ RGGSV 211_ PPQHH 216_ PSGPK 221_ SSATV 226_ SRNLN 231_ RFSTF 236_ VKSGG 241_ EAFVL 246_ GEASG 251_ FVKDG 256_ DKLCV 261_ VLGPY 266_ GPEWQ 271_ ENPYP 276_ FQCTI 281_ DDPTK 286_ QTKFK 291_ GMKSY 296_ ISYKL 301_ VPTHT 306_ QVPVH 311_ RRYKH 316_ FDWLY 321_ ARLAE 326_ KFPVI 331_ SVPHL 336_ PEKQA 341_ TGRFE 346_ EDFIS 351_ KRRKG 356_ LIWWM 361_ NHMAS 366_ HPVLA 371_ QCDVF 376_ QHFLT 381_ CPSST 386_ DEKAW 391_ KQGKR 396_ KAEKD 401_ EMVGA 406_ NFFLT 411_ LSTPP 416_ AAALD 421_ LQEVE 426_ SKIDG 431_ FKCFT 436_ KKMDD 441_ SALQL 446_ NHTAN 451_ EFARK 456_ QVTGF 461_ KKEYQ 466_ KVGQS 471_ FRGLS 476_ QAFEL 481_ DQQAF 486_ SVGLN 491_ QAIAF 496_ TGDAY 501_ DAIGE 506_ LFAEQ 511_ PRQDL 516_ DPVMD 521_ LLALY 526_ QGHLA 531_ NFPDI 536_ IHVQK 541_ GKAWP 546_ LEQVI 551_ WSVLC 556_ RLKGA 561_ TLTAV 566_ PLWVS 571_ ESYST 576_ GEEAS 581_ RDVDA 586_ WVFSL 591_ ECKLD 596_ CSTGS 601_ FLLEY 606_ LALGN 611_ EYSFS 616_ KVQRV 621_PLMTV
1: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695)