PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)
1_MEDGG 6_ LTAFE 11_ EDQRC 16_ LSQSL 21_ PLPVS 26_ AEGPA 31_ AQTTA 36_ EPSRS 41_ FSSAH 46_ RHLSR 51_ RNGLS 56_ RLCQS 61_ RTALS 66_ EDRWS 71_ SYCLS 76_ SLAAQ 81_ NICTS 86_ KLHCP 91_ AAPEH 96_ TDPSE 101_ PRGSV 106_ SCCSL 111_ LRGLS 116_ SGWSS 121_ PLLPA 126_ PVCNP 131_ NKAIF 136_ TVDAK 141_ TTEIL 146_ VANDK 151_ ACGLL 156_ GYSSQ 161_ DLIGQ 166_ KLTQF 171_ FLRSD 176_ SDVVE 181_ ALSEE 186_ HMEAD 191_ GHAAV 196_ VFGTV 201_ VDIIS 206_ RSGEK 211_ IPVSV 216_ WMKRM 221_ RQERR 226_ LCCVV 231_ VLEPV 236_ ERVST 241_ WVAFQ 246_ SDGTV 251_ TSCDS 256_ LFAHL 261_ HGYVS 266_ GEDVA 271_ GQHIT 276_ DLIPS 281_ VQLPP 286_ SGQHI 291_ PKNLK 296_ IQRSV 301_ GRARD 306_ GTTFP 311_ LSLKL 316_ KSQPS 321_ SEEAT 326_ TGEAA 331_ PVSGY 336_ RASVW 341_ VFCTI 346_ SGLIT 351_ LLPDG 356_ TIHGI 361_ NHSFA 366_ LTLFG 371_ YGKTE 376_ LLGKN 381_ ITFLI 386_ PGFYS 391_ YMDLA 396_ YNSSL 401_ QLPDL 406_ ASCLD 411_ VGNES 416_ GCGER 421_ TLDPW 426_ QGQDP 431_ AEGGQ 436_ DPRIN 441_ VVLAG 446_ GHVVP 451_ RDEIR 456_ KLMES 461_ QDIFT 466_ GTQTE 471_ LIAGG 476_ QLLSC 481_ LSPQP 486_ APGVD 491_ NVPEG 496_ SLPVH 501_ GEQAL 506_ PKDQQ 511_ ITALG 516_ REEPV 521_ AIESP 526_ GQDLL 531_ GESRS 536_ EPVDV 541_ KPFAS 546_ CEDSE 551_ APVPA 556_ EDGGS 561_ DAGMC 566_ GLCQK 571_ AQLER 576_ MGVSG 581_ PSGSD 586_ LWAGA 591_ AVAKP 596_ QAKGQ 601_ LAGGS 606_ LLMHC 611_ PCYGS 616_ EWGLW 621_ WRSQD 626_ LAPSP 631_ SGMAG 636_ LSFGT 641_ PTLDE 646_ PWLGV 651_ ENDRE 656_ ELQTC 661_ LIKEQ 666_ LSQLS 671_ LAGAL 676_ DVPHA 681_ ELVPT 686_ ECQAV 691_ TAPVS 696_ SCDLG 701_ GRDLC 706_ GGCTG 711_ SSSAC 716_ YALAT 721_ DLPGG 726_ LEAVE 731_ AQEVD 736_ VNSFS 741_ WNLKE 746_ LFFSD 751_ QTDQT 756_ SSNCS 761_ CATSE 766_ LRETP 771_ SSLAV 776_ GSDPD 781_ VGSLQ 786_ EQGSC 791_ VLDDR 796_ ELLLL 801_ TGTCV 806_ DLGQG 811_ RRFRE 816_ SCVGH 821_ DPTEP 826_ LEVCL 831_ VSSEH 836_ YAASD 841_ RESPG 846_ HVPST 851_ LDAGP 856_ EDTCP 861_ SAEEP 866_ RLNVQ 871_ VTSTP 876_ VIVMR 881_ GAAGL 886_ QREIQ 891_ EGAYS 896_ GSCYH 901_ RDGLR 906_ LSIQF 911_ EVRRV 916_ ELQGP 921_ TPLFC 926_ CWLVK 931_ DLLHS 936_ QRDSA 941_ ARTRL 946_ FLASL 951_ PGSTH 956_ STAAE 961_ LTGPS 966_ LVEVL 971_ RARPW 976_ FEEPP 981_ KAVEL 986_ EGLAA 991_ CEGEY 996_ SQKYS 1001_ TMSPL 1006_ GSGAF 1011_ GFVWT 1016_ AVDKE 1021_ KNKEV 1026_ VVKFI 1031_ KKEKV 1036_ LEDCW 1041_ IEDPK 1046_ LGKVT 1051_ LEIAI 1056_ LSRVE 1061_ HANII 1066_ KVLDI 1071_ FENQG 1076_ FFQLV 1081_ MEKHG 1086_ SGLDL 1091_ FAFID 1096_ RHPRL 1101_ DEPLA 1106_ SYIFR 1111_ QLVSA 1116_ VGYLR 1121_ LKDII 1126_ HRDIK 1131_ DENIV 1136_ IAEDF 1141_ TIKLI 1146_ DFGSA 1151_ AYLER 1156_ GKLFY 1161_ TFCGT 1166_ IEYCA 1171_ PEVLM 1176_ GNPYR 1181_ GPELE 1186_ MWSLG 1191_ VTLYT 1196_ LVFEE 1201_ NPFCE 1206_ LEETV 1211_ EAAIH 1216_ PPYLV 1221_ SKELM 1226_ SLVSG 1231_ LLQPV 1236_ PERRT 1241_ TLEKL 1246_ VTDPW 1251_ VTQPV 1256_ NLADY 1261_ TWEEV 1266_ FRVNK 1271_ PESGV 1276_ LSAAS 1281_ LEMGN 1286_ RSLSD 1291_ VAQAQ 1296_ ELCGG 1301_ PVPGE 1306_ APNGQ 1311_ GCLHP 1316_GDPRL
1: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation