BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)
1_MPRRK 6_ KKVKE 11_ VSESR 16_ NLEKK 21_ DVETT 26_ SSVSV 31_ KRKRR 36_ LEDAF 41_ IVISD 46_ SDGEE 51_ PKEEN 56_ GLQKT 61_ KTKQS 66_ NRAKC 71_ LAKRK 76_ IAQMT 81_ EEEQF 86_ ALALK 91_ MSEQE 96_ AREVN 101_ SQEEE 106_ EEELL 111_ RKAIA 116_ ESLNS 121_ CRPSD 126_ ASATR 131_ SRPLA 136_ TGPSS 141_ QSHQE 146_ KTTDS 151_ GLTEG 156_ IWQLV 161_ PPSLF 166_ KGSHI 171_ SQGNE 176_ AEERE 181_ EPWDH 186_ TEKTE 191_ EEPVS 196_ GSSGS 201_ WDQSS 206_ QPVFE 211_ NVNVK 216_ SFDRC 221_ TGHSA 226_ EHTQC 231_ GKPQE 236_ STGRG 241_ SAFLK 246_ AVQGS 251_ GDTSR 256_ HCLPT 261_ LADAK 266_ GLQDT 271_ GGTVN 276_ YFWGI 281_ PFCPD 286_ GVDPN 291_ QYTKV 296_ ILCQL 301_ EVYQK 306_ SLKMA 311_ QRQLL 316_ NKKGF 321_ GEPVL 326_ PRPPS 331_ LIQNE 336_ CGQGE 341_ QASEK 346_ NECIS 351_ EDMGD 356_ EDKEE 361_ RQESR 366_ ASDWH 371_ SKTKD 376_ FQESS 381_ IKSLK 386_ EKLLL 391_ EEEPT 396_ TSHGQ 401_ SSQGI 406_ VEETS 411_ EEGNS 416_ VPASQ 421_ SVAAL 426_ TSKRS 431_ LVLMP 436_ ESSAE 441_ EITVC 446_ PETQL 451_ SSSET 456_ FDLER 461_ EVSPG 466_ SRDIL 471_ DGVRI 476_ IMADK 481_ EVGNK 486_ EDAEK 491_ EVAIS 496_ TFSSS 501_ NQVSC 506_ PLCDQ 511_ CFPPT 516_ KIERH 521_ AMYCN 526_ GLMEE 531_ DTVLT 536_ RRQKE 541_ AKTKS 546_ DSGTA 551_ AQTSL 556_ DIDKN 561_ EKCYL 566_ CKSLV 571_ PFREY 576_ QCHVD 581_ SCLQL 586_ AKADQ 591_ GDGPE 596_ GSGRA 601_ CSTVE 606_ GKWQQ 611_ RLKNP 616_ KEKGH 621_ SEGRL 626_ LSFLE 631_ QSEHK 636_ TSDAD 641_ IKSSE 646_ TGAFR 651_ VPSPG 656_ MEEAG 661_ CSREM 666_ QSSFT 671_ RRDLN 676_ ESPVK 681_ SFVSI 686_ SEATD 691_ CLVDF 696_ KKQVT 701_ VQPGS 706_ RTRTK 711_AGRGR
1: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1