Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
1_MDVSG 6_ QETDW 11_ RSTAF 16_ RQKLV 21_ SQIED 26_ AMRKA 31_ GVAHS 36_ KSSKD 41_ MESHV 46_ FLKAK 51_ TRDEY 56_ LSLVA 61_ RLIIH 66_ FRDIH 71_ NKKSQ 76_ ASVSD 81_ PMNAL 86_ QSLTG 91_ GPAAG 96_ AAGIG 101_ MPPRG 106_ PGQSL 111_ GGMGS 116_ LGAMG 121_ QPMSL 126_ SGQPP 131_ PGTSG 136_ MAPHS 141_ MAVVS 146_ TATPQ 151_ TQLQL 156_ QQVAL 161_ QQQQQ 166_ QQQFQ 171_ QQQQA 176_ ALQQQ 181_ QQQQQ 186_ QQQFQ 191_ AQQSA 196_ MQQQF 201_ QAVVQ 206_ QQQQL 211_ QQQQQ 216_ QQQHL 221_ IKLHH 226_ QNQQQ 231_ IQQQQ 236_ QQLQR 241_ IAQLQ 246_ LQQQQ 251_ QQQQQ 256_ QQQQQ 261_ QQALQ 266_ AQPPI 271_ QQPPM 276_ QQPQP 281_ PPSQA 286_ LPQQL 291_ QQMHH 296_ TQHHQ 301_ PPPQP 306_ QQPPV 311_ AQNQP 316_ SQLPP 321_ QSQTQ 326_ PLVSQ 331_ AQALP 336_ GQMLY 341_ TQPPL 346_ KFVRA 351_ PMVVQ 356_ QPPVQ 361_ PQVQQ 366_ QQTAV 371_ QTAQA 376_ AQMVA 381_ PGVQM 386_ ITEAL 391_ AQGGM 396_ HIRAR 401_ FPPTT 406_ AVSAI 411_ PSSSI 416_ PLGRQ 421_ PMAQV 426_ SQSSL 431_ PMLSS 436_ PSPGQ 441_ QVQTP 446_ QSMPP 451_ PPQPS 456_ PQPGQ 461_ PSSQP 466_ NSNVS 471_ SGPAP 476_ SPSSF 481_ LPSPS 486_ PQPSQ 491_ SPVTA 496_ RTPQN 501_ FSVPS 506_ PGPLN 511_ TPVNP 516_ SSVMS 521_ PAGSS 526_ QAEEQ 531_ QYLDK 536_ LKQLS 541_ KYIEP 546_ LRRMI 551_ NKIDK 556_ NEDRK 561_ KDLSK 566_ MKSLL 571_ DILTD 576_ PSKRC 581_ PLKTL 586_ QKCEI 591_ ALEKL 596_ KNDMA 601_ VPTPP 606_ PPPVP 611_ PTKQQ 616_ YLCQP 621_ LLDAV 626_ LANIR 631_ SPVFN 636_ HSLYR 641_ TFVPA 646_ MTAIH 651_ GPPIT 656_ APVVC 661_ TRKRR 666_ LEDDE 671_ RQSIP 676_ SVLQG 681_ EVARL 686_ DPKFL 691_ VNLDP 696_ SHCSN 701_ NGTVH 706_ LICKL 711_ DDKDL 716_ PSVPP 721_ LELSV 726_ PADYP 731_ AQSPL 736_ WIDRQ 741_ WQYDA 746_ NPFLQ 751_ SVHRC 756_ MTSRL 761_ LQLPD 766_ KHSVT 771_ ALLNT 776_ WAQSV 781_HQACL
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway