Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
1_MSSCV 6_ SSQPS 11_ SNRAA 16_ PQDEL 21_ GGRGS 26_ SSSES 31_ QKPCE 36_ ALRGL 41_ SSLSI 46_ HLGME 51_ SFIVV 56_ TECEP 61_ GCAVD 66_ LGLAR 71_ DRPLE 76_ ADGQE 81_ VPLDT 86_ SGSQA 91_ RPHLS 96_ GRKLS 101_ LQERS 106_ QGGLA 111_ AGGSL 116_ DMNGR 121_ CICPS 126_ LPYSP 131_ VSSPQ 136_ SSPRL 141_ PRRPT 146_ VESHH 151_ VSITG 156_ MQDCV 161_ QLNQY 166_ TLKDE 171_ IGKGS 176_ YGVVK 181_ LAYNE 186_ NDNTY 191_ YAMKV 196_ LSKKK 201_ LIRQA 206_ GFPRR 211_ PPPRG 216_ TRPAP 221_ GGCIQ 226_ PRGPI 231_ EQVYQ 236_ EIAIL 241_ KKLDH 246_ PNVVK 251_ LVEVL 256_ DDPNE 261_ DHLYM 266_ VFELV 271_ NQGPV 276_ MEVPT 281_ LKPLS 286_ EDQAR 291_ FYFQD 296_ LIKGI 301_ EYLHY 306_ QKIIH 311_ RDIKP 316_ SNLLV 321_ GEDGH 326_ IKIAD 331_ FGVSN 336_ EFKGS 341_ DALLS 346_ NTVGT 351_ PAFMA 356_ PESLS 361_ ETRKI 366_ FSGKA 371_ LDVWA 376_ MGVTL 381_ YCFVF 386_ GQCPF 391_ MDERI 396_ MCLHS 401_ KIKSQ 406_ ALEFP 411_ DQPDI 416_ AEDLK 421_ DLITR 426_ MLDKN 431_ PESRI 436_ VVPEI 441_ KLHPW 446_ VTRHG 451_ AEPLP 456_ SEDEN 461_ CTLVE 466_ VTEEE 471_ VENSV 476_ KHIPS 481_ LATVI 486_ LVKTM 491_ IRKRS 496_ FGNPF 501_ EGSRR 506_ EERSL 511_ SAPGN 516_ LLTKK 521_ PTREC 526_ ESLSE 531_ LKEAR 536_ QRRQP 541_ PGHRP 546_ APRGG 551_ GGSAL 556_ VRGSP 561_ CVESC 566_ WAPAP 571_ GSPAR 576_ MHPLR 581_PEEAM
1: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching