Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)
1_MCCEK 6_ WSRVA 11_ EMFLF 16_ IEERE 21_ DCKIL 26_ CLCSR 31_ AFVED 36_ RKLYN 41_ LGLKG 46_ YYIRD 51_ SGNNS 56_ GDQAT 61_ EEEEG 66_ GYSCG 71_ TAESH 76_ DSKGI 81_ GLDES 86_ ELDSE 91_ AELMR 96_ SMGLP 101_ LQFGR 106_ ITAHK 111_ DFEVS 116_ MNTRN 121_ KVKIK 126_ KKKHQ 131_ KKYLD 136_ EIVQE 141_ SWRKE 146_ YEEDD 151_ ILASD 156_ DPSSI 161_ EQYEN 166_ TRTYE 171_ LQSKK 176_ DTETE 181_ NPPVE 186_ NTLSP 191_ KLEIT 196_ EKWEK 201_ YWNEY 206_ GGGLL 211_ WQSWQ 216_ EKHPG 221_ QALSS 226_ EPWNF 231_ PDTKE 236_ EWEQH 241_ YSQLY 246_ WYYLE 251_ QFQYW 256_ EAQGW 261_ TFDAS 266_ QSCDT 271_ DTYTS 276_ KTEAD 281_ DKNDE 286_ KCMKV 291_ DLVSF 296_ PSSPI 301_ MVDND 306_ SSGTS 311_ DKDHS 316_ EILDG 321_ ISNIK 326_ LNSEE 331_ VTQSQ 336_ LDSCT 341_ SHDGH 346_ QQLSE 351_ VSSKR 356_ ECPAS 361_ GQSEP 366_ RNGGT 371_ NEESN 376_ SSGNT 381_ NTDPP 386_ AEDSQ 391_ KSSGA 396_ NTSKD 401_ RPHAS 406_ GTDGD 411_ ESEED 416_ PPEHK 421_ PSKLK 426_ RSHEL 431_ DIDEN 436_ PASDF 441_ DDSGS 446_ LLGFK 451_ YGSGQ 456_ KYGGI 461_ PNFSH 466_ RQVRY 471_ LEKNV 476_ KLKSK 481_ YLDMR 486_ RQIKM 491_ KNKHI 496_ FFTKE 501_ SEKPF 506_ FKKSK 511_ ILSKV 516_ EKFLT 521_ WVNKP 526_ MDEEA 531_ SQESS 536_ SHDNV 541_ HDAST 546_ SSDSE 551_ EQDMS 556_ VKKGD 561_ DLLET 566_ NNPEP 571_ EKCQS 576_ VSSAG 581_ ELETE 586_ NYERD 591_ SLLAT 596_ VPDEQ 601_ DCVTQ 606_ EVPDS 611_ RQAET 616_ EAEVK 621_ KKKNK 626_ KKNKK 631_ VNGLP 636_ PEIAA 641_ VPELA 646_ KYWAQ 651_ RYRLF 656_ SRFDD 661_ GIKLD 666_ REGWF 671_ SVTPE 676_ KIAEH 681_ IAGRV 686_ SQSFK 691_ CDVVV 696_ DAFCG 701_ VGGNT 706_ IQFAL 711_ TGMRV 716_ IAIDI 721_ DPVKI 726_ ALARN 731_ NAEVY 736_ GIADK 741_ IEFIC 746_ GDFLL 751_ LASFL 756_ KADVV 761_ FLSPP 766_ WGGPD 771_ YATAE 776_ TFDIR 781_ TMMSP 786_ DGFEI 791_ FRLSK 796_ KITNN 801_ IVYFL 806_ PRNAD 811_ IDQVA 816_ SLAGP 821_ GGQVE 826_ IEQNF 831_ LNNKL 836_ KTITA 841_ YFGDL 846_IRRPA
1: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation