Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
1_MTAEL 6_ QQDDA 11_ AGAAD 16_ GHGSS 21_ CQMLL 26_ NQLRE 31_ ITGIQ 36_ DPSFL 41_ HEALK 46_ ASNGD 51_ ITQAV 56_ SLLTD 61_ ERVKE 66_ PSQDT 71_ VATEP 76_ SEVEG 81_ SAANK 86_ EVLAK 91_ VIDLT 96_ HDNKD 101_ DLQAA 106_ IALSL 111_ LESPK 116_ IQADG 121_ RDLNR 126_ MHEAT 131_ SAETK 136_ RSKRK 141_ RCEVW 146_ GENPN 151_ PNDWR 156_ RVDGW 161_ PVGLK 166_ NVGNT 171_ CWFSA 176_ VIQSL 181_ FQLPE 186_ FRRLV 191_ LSYSL 196_ PQNVL 201_ ENCRS 206_ HTEKR 211_ NIMFM 216_ QELQY 221_ LFALM 226_ MGSNR 231_ KFVDP 236_ SAALD 241_ LLKGA 246_ FRSSE 251_ EQQQD 256_ VSEFT 261_ HKLLD 266_ WLEDA 271_ FQLAV 276_ NVNSP 281_ RNKSE 286_ NPMVQ 291_ LFYGT 296_ FLTEG 301_ VREGK 306_ PFCNN 311_ ETFGQ 316_ YPLQV 321_ NGYRN 326_ LDECL 331_ EGAMV 336_ EGDVE 341_ LLPSD 346_ HSVKY 351_ GQERW 356_ FTKLP 361_ PVLTF 366_ ELSRF 371_ EFNQS 376_ LGQPE 381_ KIHNK 386_ LEFPQ 391_ IIYMD 396_ RYMYR 401_ SKELI 406_ RNKRE 411_ CIRKL 416_ KEEIK 421_ ILQQK 426_ LERYV 431_ KYGSG 436_ PARFP 441_ LPDML 446_ KYVIE 451_ FASTK 456_ PASES 461_ CPPES 466_ DTHMT 471_ LPLSS 476_ VHCSV 481_ SDQTS 486_ KESTS 491_ TESSS 496_ QDVES 501_ TFSSP 506_ EDSLP 511_ KSKPL 516_ TSSRS 521_ SMEMP 526_ SQPAP 531_ RTVTD 536_ EEINF 541_ VKTCL 546_ QRWRS 551_ EIEQD 556_ IQDLK 561_ TCIAS 566_ TTQTI 571_ EQMYC 576_ DPLLR 581_ QVPYR 586_ LHAVL 591_ VHEGQ 596_ ANAGH 601_ YWAYI 606_ YNQPR 611_ QSWLK 616_ YNDIS 621_ VTESS 626_ WEEVE 631_ RDSYG 636_ GLRNV 641_ SAYCL 646_ MYIND 651_ KLPYF 656_ NAEAA 661_ PTESD 666_ QMSEV 671_ EALSV 676_ ELKHY 681_ IQEDN 686_ WRFEQ 691_ EVEEW 696_ EEEQS 701_ CKIPQ 706_ MESST 711_ NSSSQ 716_ DYSTS 721_ QEPSV 726_ ASSHG 731_ VRCLS 736_ SEHAV 741_ IVKEQ 746_ TAQAI 751_ ANTAR 756_ AYEKS 761_ GVEAA 766_ LSEVM 771_ LSPAM 776_ QGVIL 781_ AIAKA 786_ RQTFD 791_ RDGSE 796_ AGLIK 801_ AFHEE 806_ YSRLY 811_ QLAKE 816_ TPTSH 821_ SDPRL 826_ QHVLV 831_ YFFQN 836_ EAPKR 841_ VVERT 846_ LLEQF 851_ ADKNL 856_ SYDER 861_ SISIM 866_ KVAQA 871_ KLKEI 876_ GPDDM 881_ NMEEY 886_ KKWHE 891_ DYSLF 896_ RKVSV 901_ YLLTG 906_ LELYQ 911_ KGKYQ 916_ EALSY 921_ LVYAY 926_ QSNAA 931_ LLMKG 936_ PRRGV 941_ KESVI 946_ ALYRR 951_ KCLLE 956_ LNAKA 961_ ASLFE 966_ TNDDH 971_ SVTEG 976_ INVMN 981_ ELIIP 986_ CIHLI 991_ INNDI 996_ SKDDL 1001_ DAIEV 1006_ MRNHW 1011_ CSYLG 1016_ QDIAE 1021_ NLQLC 1026_ LGEFL 1031_ PRLLD 1036_ PSAEI 1041_ IVLKE 1046_ PPTIR 1051_ PNSPY 1056_ DLCSR 1061_ FAAVM 1066_ ESIQG 1071_VSTVT
1: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306)