Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
1_MRATP 6_ LAAPA 11_ GSLSR 16_ KKRLE 21_ LDDNL 26_ DTERP 31_ VQKRA 36_ RSGPQ 41_ PRLPP 46_ CLLPL 51_ SPPTA 56_ PDRAT 61_ AVATA 66_ SRLGP 71_ YVLLE 76_ PEEGG 81_ RAYQA 86_ LHCPT 91_ GTEYT 96_ CKVYP 101_ VQEAL 106_ AVLEP 111_ YARLP 116_ PHKHV 121_ ARPTE 126_ VLAGT 131_ QLLYA 136_ FFTRT 141_ HGDMH 146_ SLVRS 151_ RHRIP 156_ EPEAA 161_ VLFRQ 166_ MATAL 171_ AHCHQ 176_ HGLVL 181_ RDLKL 186_ CRFVF 191_ ADRER 196_ KKLVL 201_ ENLED 206_ SCVLT 211_ GPDDS 216_ LWDKH 221_ ACPAY 226_ VGPEI 231_ LSSRA 236_ SYSGK 241_ AADVW 246_ SLGVA 251_ LFTML 256_ AGHYP 261_ FQDSE 266_ PVLLF 271_ GKIRR 276_ GAYAL 281_ PAGLS 286_ APARC 291_ LVRCL 296_ LRREP 301_ AERLT 306_ ATGIL 311_ LHPWL 316_ RQDPM 321_ PLAPT 326_ RSHLW 331_ EAAQV 336_ VPDGL 341_ GLDEA 346_ REEEG 351_DREVV
1: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15775988, PubMed:15781252). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15775988, PubMed:15781252). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15775988, PubMed:15781252). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230)