Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
1_MRVGP 6_ VRSAM 11_ SGASQ 16_ PRGPA 21_ LLFPA 26_ TRGVP 31_ AKRLL 36_ DADDA 41_ AAVAA 46_ KCPRL 51_ SECSS 56_ PPDYL 61_ SPPGS 66_ PCSPQ 71_ PPPAA 76_ PGAGG 81_ GSGSA 86_ PGPSR 91_ IADYL 96_ LLPLA 101_ EREHV 106_ SRALC 111_ IHTGR 116_ ELRCK 121_ VFPIK 126_ HYQDK 131_ IRPYI 136_ QLPSH 141_ SNITG 146_ IVEVI 151_ LGETK 156_ AYVFF 161_ EKDFG 166_ DMHSY 171_ VRSRK 176_ RLREE 181_ EAARL 186_ FKQIV 191_ SAVAH 196_ CHQSA 201_ IVLGD 206_ LKLRK 211_ FVFST 216_ EERTQ 221_ LRLES 226_ LEDTH 231_ IMKGE 236_ DDALS 241_ DKHGC 246_ PAYVS 251_ PEILN 256_ TTGTY 261_ SGKAA 266_ DVWSL 271_ GVMLY 276_ TLLVG 281_ RYPFH 286_ DSDPS 291_ ALFSK 296_ IRRGQ 301_ FCIPE 306_ HISPK 311_ ARCLI 316_ RSLLR 321_ REPSE 326_ RLTAP 331_ EILLH 336_ PWFES 341_ VLEPG 346_ YIDSE 351_ IGTSD 356_ QIVPE 361_ YQEDS 366_DISSF
1: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797)