GATOR complex protein WDR24 (WD repeat-containing protein 24)
1_MEKMS 6_ RVTTA 11_ LGGSV 16_ LTGRT 21_ MHCHL 26_ DAPAN 31_ AISVC 36_ RDAAQ 41_ VVVAG 46_ RSIFK 51_ IYAIE 56_ EEQFV 61_ EKLNL 66_ RVGRK 71_ PSLNL 76_ SCADV 81_ VWHQM 86_ DENLL 91_ ATAAT 96_ NGVVV 101_ TWNLG 106_ RPSRN 111_ KQDQL 116_ FTEHK 121_ RTVNK 126_ VCFHP 131_ TEAHV 136_ LLSGS 141_ QDGFM 146_ KCFDL 151_ RRKDS 156_ VSTFS 161_ GQSES 166_ VRDVQ 171_ FSIRD 176_ YFTFA 181_ STFEN 186_ GNVQL 191_ WDIRR 196_ PDRCE 201_ RMFTA 206_ HNGPV 211_ FCCDW 216_ HPEDR 221_ GWLAT 226_ GGRDK 231_ MVKVW 236_ DMTTH 241_ RAKEM 246_ HCVQT 251_ IASVA 256_ RVKWR 261_ PECRH 266_ HLATC 271_ SMMVD 276_ HNIYV 281_ WDVRR 286_ PFVPA 291_ AMFEE 296_ HRDVT 301_ TGIAW 306_ RHPHD 311_ PSFLL 316_ SGSKD 321_ SSLCQ 326_ HLFRD 331_ ASQPV 336_ ERANP 341_ EGLCY 346_ GLFGD 351_ LAFAA 356_ KESLV 361_ AAESG 366_ RKPYT 371_ GDRRH 376_ PIFFK 381_ RKLDP 386_ AEPFA 391_ GLASS 396_ ALSVF 401_ ETEPG 406_ GGGMR 411_ WFVDT 416_ AERYA 421_ LAGRP 426_ LAELC 431_ DHNAK 436_ VAREL 441_ GRNQV 446_ AQTWT 451_ MLRII 456_ YCSPG 461_ LVPTA 466_ NLNHS 471_ VGKGG 476_ SCGLP 481_ LMNSF 486_ NLKDM 491_ APGLG 496_ SETRL 501_ DRSKG 506_ DARSD 511_ TVLLD 516_ SSATL 521_ ITNED 526_ NEETE 531_ GSDVP 536_ ADYLL 541_ GDVEG 546_ EEDEL 551_ YLLDP 556_ EHAHP 561_ EDPEC 566_ VLPQE 571_ AFPLR 576_ HEIVD 581_ TPPGP 586_ EHLQD 591_ KADSP 596_ HVSGS 601_ EADVA 606_ SLAPV 611_ DSSFS 616_ LLSVS 621_ HALYD 626_ SRLPP 631_ DFFGV 636_ LVRDM 641_ LHFYA 646_ EQGDV 651_ QMAVS 656_ VLIVL 661_ GERVR 666_ KDIDE 671_ QTQEH 676_ WYTSY 681_ IDLLQ 686_ RFRLW 691_ NVSNE 696_ VVKLS 701_ TSRAV 706_ SCLNQ 711_ ASTTL 716_ HVNCS 721_ HCKRP 726_ MSSRG 731_ WVCDR 736_ CHRCA 741_ SMCAV 746_ CHHVV 751_ KGLFV 756_ WCQGC 761_ SHGGH 766_ LQHIM 771_ KWLEG 776_ SSHCP 781_AGCGH
1: Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26449471, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36732624). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26449471, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36732624). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027, PubMed:36732624). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027, PubMed:36732624). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027, PubMed:36732624)