Ras-related protein Rab-40C (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3)
1_MGSQG 6_ SPVKS 11_ YDYLL 16_ KFLLV 21_ GDSDV 26_ GKGEI 31_ LESLQ 36_ DGAAE 41_ SPYAY 46_ SNGID 51_ YKTTT 56_ ILLDG 61_ RRVKL 66_ ELWDT 71_ SGQGR 76_ FCTIF 81_ RSYSR 86_ GAQGI 91_ LLVYD 96_ ITNRW 101_ SFDGI 106_ DRWIK 111_ EIDEH 116_ APGVP 121_ RILVG 126_ NRLHL 131_ AFKRQ 136_ VPTEQ 141_ ARAYA 146_ EKNCM 151_ TFFEV 156_ SPLCN 161_ FNVIE 166_ SFTEL 171_ SRIVL 176_ MRHGM 181_ EKIWR 186_ PNRVF 191_ SLQDL 196_ CCRAI 201_ VSCTP 206_ VHLID 211_ KLPLP 216_ VTIKS 221_ HLKSF 226_ SMANG 231_ MNAVM 236_ MHGRS 241_ YSLAS 246_ GAGGG 251_ GSKGN 256_ SLKRS 261_ KSIRP 266_ PQSPP 271_ QNCSR 276_SNCKI
1: RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729)