Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1)
1_MAFSE 6_ LLDLV 11_ GGLGR 16_ FQVLQ 21_ TMALM 26_ VSIMW 31_ LCTQS 36_ MLENF 41_ SAAVP 46_ SHRCW 51_ APLLD 56_ NSTAQ 61_ ASILG 66_ SLSPE 71_ ALLAI 76_ SIPPG 81_ PNQRP 86_ HQCRR 91_ FRQPQ 96_ WQLLD 101_ PNATA 106_ TSWSE 111_ ADTEP 116_ CVDGW 121_ VYDRS 126_ IFTST 131_ IVAKW 136_ NLVCD 141_ SHALK 146_ PMAQS 151_ IYLAG 156_ ILVGA 161_ AACGP 166_ ASDRF 171_ GRRLV 176_ LTWSY 181_ LQMAV 186_ MGTAA 191_ AFAPA 196_ FPVYC 201_ LFRFL 206_ LAFAV 211_ AGVMM 216_ NTGTL 221_ LMEWT 226_ AARAR 231_ PLVMT 236_ LNSLG 241_ FSFGH 246_ GLTAA 251_ VAYGV 256_ RDWTL 261_ LQLVV 266_ SVPFF 271_ LCFLY 276_ SWWLA 281_ ESARW 286_ LLTTG 291_ RLDWG 296_ LQELW 301_ RVAAI 306_ NGKGA 311_ VQDTL 316_ TPEVL 321_ LSAMR 326_ EELSM 331_ GQPPA 336_ SLGTL 341_ LRMPG 346_ LRFRT 351_ CISTL 356_ CWFAF 361_ GFTFF 366_ GLALD 371_ LQALG 376_ SNIFL 381_ LQMFI 386_ GVVDI 391_ PAKMG 396_ ALLLL 401_ SHLGR 406_ RPTLA 411_ ASLLL 416_ AGLCI 421_ LANTL 426_ VPHEM 431_ GALRS 436_ ALAVL 441_ GLGGV 446_ GAAFT 451_ CITIY 456_ SSELF 461_ PTVLR 466_ MTAVG 471_ LGQMA 476_ ARGGA 481_ ILGPL 486_ VRLLG 491_ VHGPW 496_ LPLLV 501_ YGTVP 506_ VLSGL 511_ AALLL 516_ PETQS 521_ LPLPD 526_ TIQDV 531_ QNQAV 536_ KKATH 541_ GTLGN 546_SVLKS
1: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910)