EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)
1_MAAAR 6_ ATTPA 11_ DGEEP 16_ APEAE 21_ ALAAA 26_ RERSS 31_ RFLSG 36_ LELVK 41_ QGAEA 46_ RVFRG 51_ RFQGR 56_ AAVIK 61_ HRFPK 66_ GYRHP 71_ ALEAR 76_ LGRRR 81_ TVQEA 86_ RALLR 91_ CRRAG 96_ ISAPV 101_ VFFVD 106_ YASNC 111_ LYMEE 116_ IEGSV 121_ TVRDY 126_ IQSTM 131_ ETEKT 136_ PQGLS 141_ NLAKT 146_ IGQVL 151_ ARMHD 156_ EDLIH 161_ GDLTT 166_ SNMLL 171_ KPPLE 176_ QLNIV 181_ LIDFG 186_ LSFIS 191_ ALPED 196_ KGVDL 201_ YVLEK 206_ AFLST 211_ HPNTE 216_ TVFEA 221_ FLKSY 226_ STSSK 231_ KARPV 236_ LKKLD 241_ EVRLR 246_GRKRS
1: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)