Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1)
1_MLCSL 6_ LLCEC 11_ LLLVA 16_ GYAHD 21_ DDWID 26_ PTDML 31_ NYDAA 36_ SGTMR 41_ KSQAK 46_ YGISG 51_ EKDVS 56_ PDLSC 61_ ADEIS 66_ ECYHK 71_ LDSLT 76_ YKIDE 81_ CEKKK 86_ REDYE 91_ SQSNP 96_ VFRRY 101_ LNKIL 106_ IEAGK 111_ LGLPD 116_ ENKGD 121_ MHYDA 126_ EIILK 131_ RETLL 136_ EIQKF 141_ LNGED 146_ WKPGA 151_ LDDAL 156_ SDILI 161_ NFKFH 166_ DFETW 171_ KWRFE 176_ DSFGV 181_ DPYNV 186_ LMVLL 191_ CLLCI 196_ VVLVA 201_ TELWT 206_ YVRWY 211_ TQLRR 216_ VLIIS 221_ FLFSL 226_ GWNWM 231_ YLYKL 236_ AFAQH 241_ QAEVA 246_ KMEPL 251_ NNVCA 256_ KKMDW 261_ TGSIW 266_ EWFRS 271_ SWTYK 276_ DDPCQ 281_ KYYEL 286_ LLVNP 291_ IWLVP 296_ PTKAL 301_ AVTFT 306_ TFVTE 311_ PLKHI 316_ GKGTG 321_ EFIKA 326_ LMKEI 331_ PALLH 336_ LPVLI 341_ IMALA 346_ ILSFC 351_ YGAGK 356_ SVHVL 361_ RHIGG 366_ PESEP 371_ PQALR 376_ PRDRR 381_ RQEEI 386_ DYRPD 391_ GGAGD 396_ ADFHY 401_ RGQMG 406_ PTEQG 411_ PYAKT 416_ YEGRR 421_ EILRE 426_ RDVDL 431_ RFQTG 436_ NKSPE 441_ VLRAF 446_ DVPDA 451_ EAREH 456_ PTVVP 461_ SHKSP 466_ VLDTK 471_ PKETG 476_ GILGE 481_ GTPKE 486_ SSTES 491_ SQSAK 496_ PVSGQ 501_ DTSGN 506_ TEGSP 511_ AAEKA 516_ QLKSE 521_ AAGSP 526_ DQGST 531_ YSPAR 536_ GVAGP 541_ RGQDP 546_VSSPC
1: Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673)