Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)
1_MVDHL 6_ ANTEI 11_ NSQRI 16_ AAVES 21_ CFGAS 26_ GQPLA 31_ LPGRV 36_ LLGEG 41_ VLTKE 46_ CRKKA 51_ KPRIF 56_ FLFND 61_ ILVYG 66_ SIVLN 71_ KRKYR 76_ SQHII 81_ PLEEV 86_ TLELL 91_ PETLQ 96_ AKNRW 101_ MIKTA 106_ KKSFV 111_ VSAAS 116_ ATERQ 121_ EWISH 126_ IEECV 131_ RRQLR 136_ ATGRP 141_ PSTEH 146_ AAPWI 151_ PDKAT 156_ DICMR 161_ CTQTR 166_ FSALT 171_ RRHHC 176_ RKCGF 181_ VVCAE 186_ CSRQR 191_ FLLPR 196_ LSPKP 201_ VRVCS 206_ LCYRE 211_ LAAQQ 216_ RQEEA 221_ EEQGA 226_ GSPGQ 231_ PAHLA 236_ RPICG 241_ ASSGD 246_ DDDSD 251_ EDKEG 256_ SRDGD 261_ WPSSV 266_ EFYAS 271_GVAWS
1: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8