Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
1_MMKTE 6_ PRGPG 11_ GPLRS 16_ ASPHR 21_ SAYEA 26_ GIQAL 31_ KPPDA 36_ PGPDE 41_ APKGA 46_ HHKKY 51_ GSNVH 56_ RIKSM 61_ FLQMG 66_ TTAGP 71_ SGEAG 76_ GGAGL 81_ AEAPR 86_ ASERG 91_ VRLSL 96_ PRASS 101_ LNENV 106_ DHSAL 111_ LKLGT 116_ SVSER 121_ VSRFD 126_ SKPAP 131_ SAQPA 136_ PPPHP 141_ PSRLQ 146_ ETRKL 151_ FERSA 156_ PAAAG 161_ GDKEA 166_ AARRL 171_ LRQER 176_ AGLQD 181_ RKLDV 186_ VVRFN 191_ GSTEA 196_ LDKLD 201_ ADAVS 206_ PTVSQ 211_ LSAVF 216_ EKADS 221_ RTGLH 226_ RGPGL 231_ PRAAG 236_ VPQVN 241_ SKLVS 246_ KRSRV 251_ FQPPP 256_ PPPPA 261_ PSGDA 266_ PAEKE 271_ RCPAG 276_ QQPPQ 281_ HRVAP 286_ ARPPP 291_ KPREV 296_ RKIKP 301_ VEVEE 306_ SGESE 311_ AESAP 316_ GEVIQ 321_ AEVTV 326_ HAALE 331_ NGSTV 336_ ATAAS 341_ PAPEE 346_ PKAQA 351_ APEKE 356_ AAAVA 361_ PPERG 366_ VGNGR 371_ APDVA 376_ PEEVD 381_ ESKKE 386_ DFSEA 391_ DLVDV 396_ SAYSG 401_ LGEDS 406_ AGSAL 411_ EEDDE 416_ DDEED 421_ GEPPY 426_ EPESG 431_ CVEIP 436_ GLSEE 441_ EDPAP 446_ SRKIH 451_ FSTAP 456_ IQVFS 461_ TYSNE 466_ DYDRR 471_ NEDVD 476_ PMAAS 481_ AEYEL 486_ EKRVE 491_ RLELF 496_ PVELE 501_ KDSEG 506_ LGISI 511_ IGMGA 516_ GADMG 521_ LEKLG 526_ IFVKT 531_ VTEGG 536_ AAHRD 541_ GRIQV 546_ NDLLV 551_ EVDGT 556_ SLVGV 561_ TQSFA 566_ ASVLR 571_ NTKGR 576_ VRFMI 581_ GRERP 586_ GEQSE 591_ VAQLI 596_ QQTLE 601_ QERWQ 606_ REMME 611_ QRYAQ 616_ YGEDD 621_ EETGE 626_ YATDE 631_ DEELS 636_ PTFPG 641_ GEMAI 646_ EVFEL 651_ AENED 656_ ALSPV 661_ DMEPE 666_ KLVHK 671_ FKELQ 676_ IKHAV 681_ TEAEI 686_ QQLKR 691_ KLQSL 696_ EQEKG 701_ RWRVE 706_ KAQLE 711_ QSVEE 716_ NKERM 721_ EKLEG 726_ YWGEA 731_ QSLCQ 736_ AVDEH 741_ LRETQ 746_ AQYQA 751_ LERKY 756_ SKAKR 761_ LIKDY 766_ QQKEI 771_ EFLKK 776_ ETAQR 781_ RVLEE 786_ SELAR 791_ KEEMD 796_ KLLDK 801_ ISELE 806_ GNLQT 811_LRNSN
1: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration