Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
1_MAKRK 6_ EENFS 11_ SPKNA 16_ KRPRQ 21_ EELED 26_ FDKDG 31_ DEDEC 36_ KGTTL 41_ TAAEV 46_ GIIES 51_ IHLKN 56_ FMCHS 61_ MLGPF 66_ KFGSN 71_ VNFVV 76_ GNNGS 81_ GKSAV 86_ LTALI 91_ VGLGG 96_ RAVAT 101_ NRGSS 106_ LKGFV 111_ KDGQN 116_ SADIS 121_ ITLRN 126_ RGDDA 131_ FKASV 136_ YGNSI 141_ LIQQH 146_ ISIDG 151_ SRSYK 156_ LKSAT 161_ GSVVS 166_ TRKEE 171_ LIAIL 176_ DHFNI 181_ QVDNP 186_ VSVLT 191_ QEMSK 196_ QFLQS 201_ KNEGD 206_ KYKFF 211_ MKATQ 216_ LEQMK 221_ EDYSY 226_ IMETK 231_ ERTKE 236_ QIHQG 241_ EERLT 246_ ELKRQ 251_ CVEKE 256_ ERFQS 261_ IAGLS 266_ TMKTN 271_ LESLK 276_ HEMAW 281_ AVVNE 286_ IEKQL 291_ NAIRD 296_ NIKIG 301_ EDRAA 306_ RLDRK 311_ MEEQQ 316_ VRLNE 321_ AEQKY 326_ KDIQD 331_ KLEKI 336_ SEETN 341_ ARAPE 346_ CMALK 351_ ADVVA 356_ KKRAY 361_ NEAEV 366_ LYNRS 371_ LNEYK 376_ ALKKD 381_ DEQLC 386_ KRIEE 391_ LKKST 396_ DQSLE 401_ PERLE 406_ RQKKI 411_ SWLKE 416_ RVKAF 421_ QNQEN 426_ SVNQE 431_ IEQFQ 436_ QAIEK 441_ DKEEH 446_ GKIKR 451_ EELDV 456_ KHALS 461_ YNQRQ 466_ LKELK 471_ DSKTD 476_ RLKRF 481_ GPNVP 486_ ALLEA 491_ IDDAY 496_ RQGHF 501_ TYKPV 506_ GPLGA 511_ CIHLR 516_ DPELA 521_ LAIES 526_ CLKGL 531_ LQAYC 536_ CHNHA 541_ DERVL 546_ QALMK 551_ RFYLP 556_ GTSRP 561_ PIIVS 566_ EFRNE 571_ IYDVR 576_ HRAAY 581_ HPDFP 586_ TVLTA 591_ LEIDN 596_ AVVAN 601_ SLIDM 606_ RGIET 611_ VLLIK 616_ NNSVA 621_ RAVMQ 626_ SQKPP 631_ KNCRE 636_ AFTAD 641_ GDQVF 646_ AGRYY 651_ SSENT 656_ RPKFL 661_ SRDVD 666_ SEISD 671_ LENEV 676_ ENKTA 681_ QILNL 686_ QQHLS 691_ ALEKD 696_ IKHNE 701_ ELLKR 706_ CQLHY 711_ KELKM 716_ KIRKN 721_ ISEIR 726_ ELENI 731_ EEHQS 736_ VDIAT 741_ LEDEA 746_ QENKS 751_ KMKMV 756_ EEHME 761_ QQKEN 766_ MEHLK 771_ SLKIE 776_ AENKY 781_ DAIKF 786_ KINQL 791_ SELAD 796_ PLKDE 801_ LNLAD 806_ SEVDN 811_ QKRGK 816_ RHYEE 821_ KQKEH 826_ LDTLN 831_ KKKRE 836_ LDMKE 841_ KELEE 846_ KMSQA 851_ RQICP 856_ ERIEV 861_ EKSAS 866_ ILDKE 871_ INRLR 876_ QKIQA 881_ EHASH 886_ GDREE 891_ IMRQY 896_ QEARE 901_ TYLDL 906_ DSKVR 911_ TLKKF 916_ IKLLG 921_ EIMEH 926_ RFKTY 931_ QQFRR 936_ CLTLR 941_ CKLYF 946_ DNLLS 951_ QRAYC 956_ GKMNF 961_ DHKNE 966_ TLSIS 971_ VQPGE 976_ GNKAA 981_ FNDMR 986_ ALSGG 991_ ERSFS 996_ TVCFI 1001_ LSLWS 1006_ IAESP 1011_ FRCLD 1016_ EFDVY 1021_ MDMVN 1026_ RRIAM 1031_ DLILK 1036_ MADSQ 1041_ RFRQF 1046_ ILLTP 1051_ QSMSS 1056_ LPSSK 1061_ LIRIL 1066_ RMSDP 1071_ ERGQT 1076_ TLPFR 1081_ PVTQE 1086_EDDDQ
1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541)