Cytochrome P450 2S1 (EC 1.14.14.-) (CYPIIS1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Thromboxane-A synthase) (EC 5.3.99.5)
1_MEATG 6_ TWALL 11_ LALAL 16_ LLLLT 21_ LALSG 26_ TRARG 31_ HLPPG 36_ PTPLP 41_ LLGNL 46_ LQLRP 51_ GALYS 56_ GLMRL 61_ SKKYG 66_ PVFTI 71_ YLGPW 76_ RPVVV 81_ LVGQE 86_ AVREA 91_ LGGQA 96_ EEFSG 101_ RGTVA 106_ MLEGT 111_ FDGHG 116_ VFFSN 121_ GERWR 126_ QLRKF 131_ TMLAL 136_ RDLGM 141_ GKREG 146_ EELIQ 151_ AEARC 156_ LVETF 161_ QGTEG 166_ RPFDP 171_ SLLLA 176_ QATSN 181_ VVCSL 186_ LFGLR 191_ FSYED 196_ KEFQA 201_ VVRAA 206_ GGTLL 211_ GVSSQ 216_ GGQTY 221_ EMFSW 226_ FLRPL 231_ PGPHK 236_ QLLHH 241_ VSTLA 246_ AFTVR 251_ QVQQH 256_ QGNLD 261_ ASGPA 266_ RDLVD 271_ AFLLK 276_ MAQEE 281_ QNPGT 286_ EFTNK 291_ NMLMT 296_ VIYLL 301_ FAGTM 306_ TVSTT 311_ VGYTL 316_ LLLMK 321_ YPHVQ 326_ KWVRE 331_ ELNRE 336_ LGAGQ 341_ APSLG 346_ DRTRL 351_ PYTDA 356_ VLHEA 361_ QRLLA 366_ LVPMG 371_ IPRTL 376_ MRTTR 381_ FRGYT 386_ LPQGT 391_ EVFPL 396_ LGSIL 401_ HDPNI 406_ FKHPE 411_ EFNPD 416_ RFLDA 421_ DGRFR 426_ KHEAF 431_ LPFSL 436_ GKRVC 441_ LGEGL 446_ AKAEL 451_ FLFFT 456_ TILQA 461_ FSLES 466_ PCPPD 471_ TLSLK 476_ PTVSG 481_ LFNIP 486_ PAFQL 491_ QVRPT 496_DLHST
1: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195)