Protein IWS1 homolog (IWS1-like protein)
1_MDSEY 6_ YSGDQ 11_ SDDGG 16_ ATPVQ 21_ DERDS 26_ GSDGE 31_ DDVNE 36_ QHSGS 41_ DTGSV 46_ ERHSE 51_ NETSD 56_ REDGL 61_ PKGHH 66_ VTDSE 71_ NDEPL 76_ NLNAS 81_ DSESE 86_ ELHRQ 91_ KDSDS 96_ ESEER 101_ AEPPA 106_ SDSEN 111_ EDVNQ 116_ HGSDS 121_ ESEET 126_ RKLPG 131_ SDSEN 136_ EELLN 141_ GHASD 146_ SENED 151_ VGKHP 156_ ASDSE 161_ IEELQ 166_ KSPAS 171_ DSETE 176_ DALKP 181_ QISDS 186_ ESEEP 191_ PRHQA 196_ SDSEN 201_ EEPPK 206_ PRMSD 211_ SESEE 216_ LPKPQ 221_ VSDSE 226_ SEEPP 231_ RHQAS 236_ DSENE 241_ ELPKP 246_ RISDS 251_ ESEDP 256_ PRHQA 261_ SDSEN 266_ EELPK 271_ PRISD 276_ SESED 281_ PPRNQ 286_ ASDSE 291_ NEELP 296_ KPRVS 301_ DSESE 306_ GPQKG 311_ PASDS 316_ ETEDA 321_ SRHKQ 326_ KPESD 331_ DDSDR 336_ ENKGE 341_ DTEMQ 346_ NDSFH 351_ SDSHM 356_ DRKKF 361_ HSSDS 366_ EEEEH 371_ KKQKM 376_ DSDED 381_ EKEGE 386_ EEKVA 391_ KRKAA 396_ VLSDS 401_ EDEEK 406_ ASAKK 411_ SRVVS 416_ DADDS 421_ DSDAV 426_ SDKSG 431_ KREKT 436_ IASDS 441_ EEEAG 446_ KELSD 451_ KKNEE 456_ KDLFG 461_ SDSES 466_ GNEEE 471_ NLIAD 476_ IFGES 481_ GDEEE 486_ EEFTG 491_ FNQED 496_ LEEEK 501_ GETQV 506_ KEAED 511_ SDSDD 516_ NIKRG 521_ KHMDF 526_ LSDFE 531_ MMLQR 536_ KKSMS 541_ GKRRR 546_ NRDGG 551_ TFISD 556_ ADDVV 561_ SAMIV 566_ KMNEA 571_ AEEDR 576_ QLNNQ 581_ KKPAL 586_ KKLTL 591_ LPAVV 596_ MHLKK 601_ QDLKE 606_ TFIDS 611_ GVMSA 616_ IKEWL 621_ SPLPD 626_ RSLPA 631_ LKIRE 636_ ELLKI 641_ LQELP 646_ SVSQE 651_ TLKHS 656_ GIGRA 661_ VMYLY 666_ KHPKE 671_ SRSNK 676_ DMAGK 681_ LINEW 686_ SRPIF 691_ GLTSN 696_ YKGMT 701_ REERE 706_ QRDLE 711_ QMPQR 716_ RRMNS 721_ TGGQT 726_ PRRDL 731_ EKVLT 736_ GEEKA 741_ LRPGD 746_ PGFCA 751_ RARVP 756_ MPSNK 761_ DYVVR 766_ PKWNV 771_ EMESS 776_ RFQAT 781_ SKKGI 786_ SRLDK 791_ QMRKF 796_ TDIRK 801_ KSRSA 806_ HAVKI 811_SIEGN
1: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription