Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
1_MKRRL 6_ DDQES 11_ PVYAA 16_ QQRRI 21_ PGSTE 26_ AFPHQ 31_ HRVLA 36_ PAPPV 41_ YEAVS 46_ ETMQS 51_ ATGIQ 56_ YSVTP 61_ SYQVS 66_ AMPQS 71_ SGSHG 76_ PAIAA 81_ VHSSH 86_ HHPTA 91_ VQPHG 96_ GQVVQ 101_ SHAHP 106_ APPVA 111_ PVQGQ 116_ QQFQR 121_ LKVED 126_ ALSYL 131_ DQVKL 136_ QFGSQ 141_ PQVYN 146_ DFLDI 151_ MKEFK 156_ SQSID 161_ TPGVI 166_ SRVSQ 171_ LFKGH 176_ PDLIM 181_ GFNTF 186_ LPPGY 191_ KIEVQ 196_ TNDMV 201_ NVTTP 206_ GQVHQ 211_ IPTHG 216_ IQPQP 221_ QPPPQ 226_ HPSQP 231_ SAQSA 236_ PAPAQ 241_ PAPQP 246_ PPAKV 251_ SKPSQ 256_ LQAHT 261_ PASQQ 266_ TPPLP 271_ PYASP 276_ RSPPV 281_ QPHTP 286_ VTISL 291_ GTAPS 296_ LQNNQ 301_ PVEFN 306_ HAINY 311_ VNKIK 316_ NRFQG 321_ QPDIY 326_ KAFLE 331_ ILHTY 336_ QKEQR 341_ NAKEA 346_ GGNYT 351_ PALTE 356_ QEVYA 361_ QVARL 366_ FKNQE 371_ DLLSE 376_ FGQFL 381_ PDANS 386_ SVLLS 391_ KTTAE 396_ KVDSV 401_ RNDHG 406_ GTVKK 411_ PQLNN 416_ KPQRP 421_ SQNGC 426_ QIRRH 431_ PTGTT 436_ PPVKK 441_ KPKLL 446_ NLKDS 451_ SMADA 456_ SKHGG 461_ GTESL 466_ FFDKV 471_ RKALR 476_ SAEAY 481_ ENFLR 486_ CLVIF 491_ NQEVI 496_ SRAEL 501_ VQLVS 506_ PFLGK 511_ FPELF 516_ NWFKN 521_ FLGYK 526_ ESVHL 531_ ETYPK 536_ ERATE 541_ GIAME 546_ IDYAS 551_ CKRLG 556_ SSYRA 561_ LPKSY 566_ QQPKC 571_ TGRTP 576_ LCKEV 581_ LNDTW 586_ VSFPS 591_ WSEDS 596_ TFVSS 601_ KKTQY 606_ EEHIY 611_ RCEDE 616_ RFELD 621_ VVLET 626_ NLATI 631_ RVLEA 636_ IQKKL 641_ SRLSA 646_ EEQAK 651_ FRLDN 656_ TLGGT 661_ SEVIH 666_ RKALQ 671_ RIYAD 676_ KAADI 681_ IDGLR 686_ KNPSI 691_ AVPIV 696_ LKRLK 701_ MKEEE 706_ WREAQ 711_ RGFNK 716_ VWREQ 721_ NEKYY 726_ LKSLD 731_ HQGIN 736_ FKQND 741_ TKVLR 746_ SKSLL 751_ NEIES 756_ IYDER 761_ QEQAT 766_ EENAG 771_ VPVGP 776_ HLSLA 781_ YEDKQ 786_ ILEDA 791_ AALII 796_ HHVKR 801_ QTGIQ 806_ KEDKY 811_ KIKQI 816_ MHHFI 821_ PDLLF 826_ AQRGD 831_ LSDVE 836_ EEEEE 841_ EMDVD 846_ EATGA 851_ VKKHN 856_ GVGGS 861_ PPKSK 866_ LLFSN 871_ TAAQK 876_ LRGMD 881_ EVYNL 886_ FYVNN 891_ NWYIF 896_ MRLHQ 901_ ILCLR 906_ LLRIC 911_ SQAER 916_ QIEEE 921_ NRERE 926_ WEREV 931_ LGIKR 936_ DKSDS 941_ PAIQL 946_ RLKEP 951_ MDVDV 956_ EDYYP 961_ AFLDM 966_ VRSLL 971_ DGNID 976_ SSQYE 981_ DSLRE 986_ MFTIH 991_ AYIAF 996_ TMDKL 1001_ IQSIV 1006_ RQLQH 1011_ IVSDE 1016_ ICVQV 1021_ TDLYL 1026_ AENNN 1031_ GATGG 1036_ QLNTQ 1041_ NSRSL 1046_ LESTY 1051_ QRKAE 1056_ QLMSD 1061_ ENCFK 1066_ LMFIQ 1071_ SQGQV 1076_ QLTIE 1081_ LLDTE 1086_ EENSD 1091_ DPVEA 1096_ ERWSD 1101_ YVERY 1106_ MNSDT 1111_ TSPEL 1116_ REHLA 1121_ QKPVF 1126_ LPRNL 1131_ RRIRK 1136_ CQRGR 1141_ EQQEK 1146_ EGKEG 1151_ NSKKT 1156_ MENVD 1161_ SLDKL 1166_ ECRFK 1171_ LNSYK 1176_ MVYVI 1181_ KSEDY 1186_ MYRRT 1191_ ALLRA 1196_ HQSHE 1201_ RVSKR 1206_ LHQRF 1211_ QAWVD 1216_ KWTKE 1221_ HVPRE 1226_ MAAET 1231_ SKWLM 1236_ GEGLE 1241_ GLVPC 1246_ TTTCD 1251_ TETLH 1256_ FVSIN 1261_ KYRVK 1266_YGTVF
1: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity)